5-MeO-T-NBOMe

Psychedelic drug

5-MeO-T-NBOMe
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CAS Number	1539264-32-0
PubChem	57339128
DrugBank
ChemSpider	29341884
KEGG

5-MeO-T-NBOMe is a synthetic psychedelic compound belonging to the NBOMe class. It is a derivative of the tryptamine 5-MeO-T, modified with a 2-methoxybenzyl group. This compound is known for its potent hallucinogenic effects and has been used in psychedelic research and recreationally.

Chemical Structure and Properties

Chemical structure of 5-MeO-T-NBOMe

5-MeO-T-NBOMe is chemically classified as a tryptamine derivative. Its full chemical name is 2-(5-Methoxy-1H-indol-3-yl)-N-(2-methoxybenzyl)ethanamine. The compound features a methoxy group at the 5-position of the indole ring and a 2-methoxybenzyl group attached to the nitrogen atom of the ethylamine chain. This structural modification is responsible for its high affinity for the serotonin receptors, particularly the 5-HT_2A receptor, which is believed to mediate its psychedelic effects.

Pharmacology

5-MeO-T-NBOMe acts primarily as a potent agonist of the 5-HT_2A receptor, similar to other compounds in the NBOMe series. This receptor is a subtype of the serotonin receptor and is heavily involved in the modulation of mood, perception, and cognition. The activation of this receptor by 5-MeO-T-NBOMe leads to altered sensory perception and hallucinations.

Effects

The effects of 5-MeO-T-NBOMe are similar to those of other psychedelic substances, such as LSD and psilocybin. Users report intense visual and auditory hallucinations, changes in perception of time and space, and profound alterations in thought processes. The onset of effects is rapid, often occurring within 30 minutes of ingestion, and can last for several hours.

Safety and Toxicity

The safety profile of 5-MeO-T-NBOMe is not well-established, and its use carries significant risks. There have been reports of severe adverse effects, including vasoconstriction, hypertension, and tachycardia. In some cases, use of the compound has led to hospitalization and even death. Due to its potency and the potential for overdose, caution is advised when handling or using this substance.

Legal Status

The legal status of 5-MeO-T-NBOMe varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. It is important for individuals to be aware of the legal implications of possessing or distributing this compound in their region.

Related Compounds

5-MeO-T-NBOMe is related to other compounds in the NBOMe series, such as 25I-NBOMe and 25C-NBOMe, which also act as potent 5-HT_2A receptor agonists. These compounds share similar effects and risks, and are often encountered in the context of recreational drug use.

Related Pages

• NBOMe series
• Psychedelic drug
• Serotonin receptor
• Tryptamine