4'-Fluoro-α-pyrrolidinopentiophenone

Synthetic stimulant of the cathinone class

4'-Fluoro-α-pyrrolidinopentiophenone
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CAS Number	13415-87-7
PubChem	119025
DrugBank
ChemSpider	106282
KEGG

4'-Fluoro-α-pyrrolidinopentiophenone (also known as 4F-PVP) is a synthetic stimulant of the cathinone class that has been sold online as a designer drug. It is a fluorinated derivative of α-pyrrolidinopentiophenone (α-PVP).

Chemical structure and properties

Chemical structure of 4'-Fluoro-α-pyrrolidinopentiophenone

4'-Fluoro-α-pyrrolidinopentiophenone is a substituted cathinone, which is a class of compounds related to the naturally occurring khat plant. The chemical structure of 4F-PVP includes a pyrrolidine ring, which is a common feature in this class of compounds, and a fluorine atom attached to the phenyl ring, which distinguishes it from its non-fluorinated analogs.

The presence of the fluorine atom is thought to influence the compound's lipophilicity, metabolism, and pharmacokinetics, potentially altering its psychoactive effects compared to non-fluorinated analogs.

Pharmacology

4'-Fluoro-α-pyrrolidinopentiophenone acts as a norepinephrine-dopamine reuptake inhibitor (NDRI), similar to other synthetic cathinones. This mechanism of action leads to increased concentrations of norepinephrine and dopamine in the synaptic cleft, resulting in stimulant effects.

The pharmacological effects of 4F-PVP are not well-studied, but it is believed to produce effects similar to those of other synthetic cathinones, such as increased alertness, euphoria, and stimulation. However, the specific effects and potential toxicity of 4F-PVP have not been thoroughly investigated in scientific studies.

Legal status

The legal status of 4'-Fluoro-α-pyrrolidinopentiophenone varies by country. In many jurisdictions, it is considered a controlled substance due to its structural similarity to other banned synthetic cathinones. In the United States, for example, it may be considered an analog of a controlled substance under the Federal Analogue Act.

Health risks and safety

The use of 4F-PVP, like other synthetic cathinones, is associated with a range of potential health risks. These can include cardiovascular issues, neurological effects, and psychiatric symptoms. The lack of research on this specific compound means that its full risk profile is not well understood, but caution is advised due to the potential for adverse effects.

Related pages

• Cathinone
• Synthetic cathinones
• Designer drug
• Norepinephrine-dopamine reuptake inhibitor