AMN082

AMN082

Chemical structure of AMN082

AMN082 is a chemical compound that acts as a selective agonist for the metabotropic glutamate receptor subtype mGluR7. It is primarily used in scientific research to study the function of this receptor in the central nervous system.

Mechanism of Action

AMN082 functions by binding to and activating the mGluR7 receptor, which is a member of the group III metabotropic glutamate receptors. These receptors are coupled to G-proteins and are involved in modulating neurotransmission in the brain. Activation of mGluR7 by AMN082 leads to the inhibition of adenylyl cyclase activity, resulting in decreased levels of cyclic AMP within the cell.

Pharmacological Effects

The activation of mGluR7 by AMN082 has been shown to produce a variety of effects in the nervous system. These include modulation of synaptic transmission, influence on neurotransmitter release, and potential neuroprotective effects. AMN082 has been used in research to explore its potential therapeutic applications in neurological disorders such as anxiety, depression, and schizophrenia.

Research Applications

AMN082 is widely used in neuroscience research to investigate the role of mGluR7 in various physiological and pathological processes. Studies have utilized AMN082 to:

• Examine the role of mGluR7 in synaptic plasticity and memory formation.
• Investigate the potential of mGluR7 as a target for antidepressant and anxiolytic therapies.
• Explore the involvement of mGluR7 in pain modulation and nociception.

Safety and Toxicity

While AMN082 is a valuable tool in research, its safety profile in humans is not well-established, as it is primarily used in preclinical studies. Researchers must handle AMN082 with care, following appropriate safety protocols to avoid potential adverse effects.

Related Pages

• Metabotropic glutamate receptor
• Neurotransmitter
• G-protein coupled receptor
• Synaptic transmission