Imidazole
Imidazole is an organic compound with the formula C3H4N2. This aromatic heterocyclic is a diazole and one of the fundamental units of the vast class of histidine and histamine.
Structure and properties
Imidazole is a 5-membered planar ring, which is soluble in water and forms a tautomeric equilibrium. That is, the compound can be represented by two tautomeric chemical structures, the aromatic one being more stable than the open-chain form.
Preparation
Imidazole can be synthesized by numerous methods besides the Debus method. Many of these syntheses can also be applied to different substituted imidazoles.
Applications
Imidazole is incorporated into many important biological molecules. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.
Safety
Imidazole is amphoteric, that is, it can function as both an acid and as a base. As an acid, the pKa of imidazole is 14.05, making it less acidic than carboxylic acids, phenols, and imides, but slightly more acidic than alcohols.
See also
References
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