ADB-BINACA

Synthetic cannabinoid

ADB-BINACA
INN
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CAS Number	1185887-21-1
PubChem	11902592
DrugBank
ChemSpider	58191434
KEGG

ADB-BINACA is a synthetic cannabinoid that has been used in synthetic cannabis products. It is a potent agonist of the cannabinoid receptors, specifically the CB1 receptor.

Chemical structure and properties

ADB-BINACA is classified as an indazole-based synthetic cannabinoid. Its chemical structure includes an indazole core, which is a bicyclic structure composed of a benzene ring fused to a pyrazole ring. The compound is further characterized by a carboxamide group at the 3-position of the indazole ring, and a butyl chain at the 1-position.

The IUPAC name for ADB-BINACA is N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-butyl-1H-indazole-3-carboxamide. The presence of the tert-leucine moiety in its structure is a distinguishing feature, contributing to its high affinity for cannabinoid receptors.

Pharmacology

ADB-BINACA acts as a potent agonist at the CB1 receptor, which is primarily responsible for the psychoactive effects of cannabinoids. The activation of CB1 receptors by ADB-BINACA can lead to effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

The compound's high potency and efficacy at the CB1 receptor make it a subject of concern for public health, as it can lead to severe adverse effects, including psychosis, tachycardia, and hypertension.

Legal status

Due to its potential for abuse and adverse health effects, ADB-BINACA has been classified as a controlled substance in several countries. Regulatory agencies have placed it under various schedules to restrict its distribution and use.

Synthesis

The synthesis of ADB-BINACA involves the formation of the indazole core, followed by the introduction of the carboxamide group and the butyl chain. The synthesis process requires careful control of reaction conditions to ensure the correct formation of the desired isomer.

Health effects

The use of ADB-BINACA has been associated with a range of adverse health effects. Users may experience symptoms such as anxiety, paranoia, hallucinations, and seizures. The compound's high potency increases the risk of overdose and severe toxicological outcomes.

Related pages

• Synthetic cannabinoids
• Cannabinoid receptor
• Tetrahydrocannabinol
• Synthetic cannabis