Narcotoline

Narcotoline is an opiate alkaloid that is found in opium. It is a minor constituent of opium, accounting for less than 1% of the total alkaloid content. Despite its low concentration, narcotoline has been the subject of scientific research due to its potential pharmacological properties.

Chemistry

Narcotoline is a member of the benzylisoquinoline class of alkaloids. It is structurally related to other opiate alkaloids such as morphine, codeine, and thebaine. The chemical structure of narcotoline consists of a benzylisoquinoline core, with additional functional groups that contribute to its pharmacological activity.

Pharmacology

The pharmacological properties of narcotoline are not well understood. As an opiate alkaloid, it is believed to interact with the opioid receptors in the brain, potentially producing analgesic effects. However, the potency and efficacy of narcotoline at these receptors is not known. Further research is needed to fully elucidate the pharmacological activity of this compound.

Toxicology

The toxicological profile of narcotoline is also not well characterized. As a minor constituent of opium, it is likely to contribute to the overall toxicity of this substance. However, the specific toxic effects of narcotoline, as well as its lethal dose, are not known.

History and Legal Status

Narcotoline was first isolated from opium in the 19th century. Its chemical structure was determined in the early 20th century. Currently, narcotoline is not specifically regulated under international drug control treaties. However, as a constituent of opium, it is indirectly controlled under the provisions that regulate opium and its derivatives.

See Also

• Opium
• Opiate
• Benzylisoquinoline
• Opioid receptor

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