Molybdenum deficiency: Difference between revisions
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{{Infobox medical condition | |||
| name = Molybdenum deficiency | |||
| image = [[File:Mo-TableImage.svg|150px]] | |||
| caption = Molybdenum on the periodic table | |||
| field = [[Endocrinology]] | |||
| symptoms = [[Tachycardia]], [[headache]], [[nausea]], [[vomiting]], [[central scotoma]], [[coma]] | |||
| complications = [[Neurological damage]], [[seizures]] | |||
| onset = Can occur in [[infancy]] or later in life | |||
| duration = Varies depending on treatment | |||
| causes = [[Dietary deficiency]], [[genetic disorders]] | |||
| risks = [[Total parenteral nutrition]], [[genetic mutations]] | |||
| diagnosis = [[Blood test]], [[urine test]] | |||
| differential = [[Copper deficiency]], [[zinc deficiency]] | |||
| prevention = Adequate dietary intake of [[molybdenum]] | |||
| treatment = [[Molybdenum supplementation]], [[dietary management]] | |||
| prognosis = Good with treatment | |||
| frequency = Rare | |||
}} | |||
{{DISPLAYTITLE:Molybdenum Deficiency}} | {{DISPLAYTITLE:Molybdenum Deficiency}} | ||
'''Molybdenum deficiency''' is a rare nutritional disorder that occurs when there is an insufficient amount of [[molybdenum]] in the diet. Molybdenum is an essential trace element that is crucial for the function of certain enzymes in the human body. These enzymes are involved in the metabolism of sulfur-containing amino acids and the detoxification of certain harmful compounds. | '''Molybdenum deficiency''' is a rare nutritional disorder that occurs when there is an insufficient amount of [[molybdenum]] in the diet. Molybdenum is an essential trace element that is crucial for the function of certain enzymes in the human body. These enzymes are involved in the metabolism of sulfur-containing amino acids and the detoxification of certain harmful compounds. | ||
== Causes == | == Causes == | ||
Molybdenum deficiency can occur due to inadequate dietary intake, malabsorption syndromes, or genetic disorders affecting molybdenum metabolism. It is more likely to occur in individuals receiving long-term [[parenteral nutrition]] without adequate molybdenum supplementation. | Molybdenum deficiency can occur due to inadequate dietary intake, malabsorption syndromes, or genetic disorders affecting molybdenum metabolism. It is more likely to occur in individuals receiving long-term [[parenteral nutrition]] without adequate molybdenum supplementation. | ||
== Symptoms == | == Symptoms == | ||
The symptoms of molybdenum deficiency can include: | The symptoms of molybdenum deficiency can include: | ||
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* Night blindness | * Night blindness | ||
* Increased levels of sulfite and decreased levels of sulfate in the urine | * Increased levels of sulfite and decreased levels of sulfate in the urine | ||
== Biochemical Role == | == Biochemical Role == | ||
Molybdenum is a cofactor for several important enzymes, including: | Molybdenum is a cofactor for several important enzymes, including: | ||
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* [[Xanthine oxidase]], which plays a role in the breakdown of purines | * [[Xanthine oxidase]], which plays a role in the breakdown of purines | ||
* [[Aldehyde oxidase]], which is involved in the metabolism of aldehydes | * [[Aldehyde oxidase]], which is involved in the metabolism of aldehydes | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of molybdenum deficiency is based on clinical symptoms, dietary history, and laboratory tests. Laboratory tests may show elevated levels of sulfite and decreased levels of sulfate in the urine. Genetic testing may be performed to identify mutations in genes related to molybdenum metabolism. | Diagnosis of molybdenum deficiency is based on clinical symptoms, dietary history, and laboratory tests. Laboratory tests may show elevated levels of sulfite and decreased levels of sulfate in the urine. Genetic testing may be performed to identify mutations in genes related to molybdenum metabolism. | ||
== Treatment == | == Treatment == | ||
Treatment of molybdenum deficiency involves dietary supplementation with molybdenum. This can be achieved through oral supplements or by adjusting the composition of parenteral nutrition solutions. Monitoring of molybdenum levels and clinical symptoms is important to ensure adequate treatment. | Treatment of molybdenum deficiency involves dietary supplementation with molybdenum. This can be achieved through oral supplements or by adjusting the composition of parenteral nutrition solutions. Monitoring of molybdenum levels and clinical symptoms is important to ensure adequate treatment. | ||
== Prevention == | == Prevention == | ||
Ensuring an adequate intake of molybdenum through a balanced diet is the primary method of preventing molybdenum deficiency. Foods rich in molybdenum include legumes, grains, and organ meats. | Ensuring an adequate intake of molybdenum through a balanced diet is the primary method of preventing molybdenum deficiency. Foods rich in molybdenum include legumes, grains, and organ meats. | ||
== See also == | |||
== | |||
* [[Trace element]] | * [[Trace element]] | ||
* [[Enzyme cofactor]] | * [[Enzyme cofactor]] | ||
* [[Parenteral nutrition]] | * [[Parenteral nutrition]] | ||
* [[Metabolism]] | * [[Metabolism]] | ||
[[Category:Nutritional deficiencies]] | [[Category:Nutritional deficiencies]] | ||
[[Category:Trace elements]] | [[Category:Trace elements]] | ||
Latest revision as of 04:03, 8 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Molybdenum deficiency | |
|---|---|
| |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Tachycardia, headache, nausea, vomiting, central scotoma, coma |
| Complications | Neurological damage, seizures |
| Onset | Can occur in infancy or later in life |
| Duration | Varies depending on treatment |
| Types | N/A |
| Causes | Dietary deficiency, genetic disorders |
| Risks | Total parenteral nutrition, genetic mutations |
| Diagnosis | Blood test, urine test |
| Differential diagnosis | Copper deficiency, zinc deficiency |
| Prevention | Adequate dietary intake of molybdenum |
| Treatment | Molybdenum supplementation, dietary management |
| Medication | N/A |
| Prognosis | Good with treatment |
| Frequency | Rare |
| Deaths | N/A |
Molybdenum deficiency is a rare nutritional disorder that occurs when there is an insufficient amount of molybdenum in the diet. Molybdenum is an essential trace element that is crucial for the function of certain enzymes in the human body. These enzymes are involved in the metabolism of sulfur-containing amino acids and the detoxification of certain harmful compounds.
Causes[edit]
Molybdenum deficiency can occur due to inadequate dietary intake, malabsorption syndromes, or genetic disorders affecting molybdenum metabolism. It is more likely to occur in individuals receiving long-term parenteral nutrition without adequate molybdenum supplementation.
Symptoms[edit]
The symptoms of molybdenum deficiency can include:
- Neurological abnormalities such as seizures and developmental delays
- Increased heart rate and respiratory rate
- Night blindness
- Increased levels of sulfite and decreased levels of sulfate in the urine
Biochemical Role[edit]
Molybdenum is a cofactor for several important enzymes, including:
- Sulfite oxidase, which is involved in the metabolism of sulfur-containing amino acids
- Xanthine oxidase, which plays a role in the breakdown of purines
- Aldehyde oxidase, which is involved in the metabolism of aldehydes
Diagnosis[edit]
Diagnosis of molybdenum deficiency is based on clinical symptoms, dietary history, and laboratory tests. Laboratory tests may show elevated levels of sulfite and decreased levels of sulfate in the urine. Genetic testing may be performed to identify mutations in genes related to molybdenum metabolism.
Treatment[edit]
Treatment of molybdenum deficiency involves dietary supplementation with molybdenum. This can be achieved through oral supplements or by adjusting the composition of parenteral nutrition solutions. Monitoring of molybdenum levels and clinical symptoms is important to ensure adequate treatment.
Prevention[edit]
Ensuring an adequate intake of molybdenum through a balanced diet is the primary method of preventing molybdenum deficiency. Foods rich in molybdenum include legumes, grains, and organ meats.
