Hereditary diffuse gastric cancer: Difference between revisions
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{{Infobox medical condition | |||
| name = Hereditary diffuse gastric cancer | |||
| image = [[File:Total_gastrectomy_with_Roux-en-Y.png|250px]] | |||
| caption = Total gastrectomy with Roux-en-Y reconstruction, a surgical treatment for hereditary diffuse gastric cancer | |||
| field = [[Oncology]], [[Gastroenterology]], [[Genetics]] | |||
| symptoms = [[Stomach pain]], [[nausea]], [[vomiting]], [[weight loss]], [[anemia]] | |||
| complications = [[Metastasis]], [[malnutrition]], [[anemia]] | |||
| onset = Typically in [[adulthood]] | |||
| duration = [[Chronic (medicine)|Chronic]] | |||
| causes = [[Genetic mutation]] in the [[CDH1]] gene | |||
| risks = Family history of the condition, [[genetic predisposition]] | |||
| diagnosis = [[Genetic testing]], [[endoscopy]], [[biopsy]] | |||
| differential = [[Sporadic gastric cancer]], [[Peptic ulcer disease]], [[Gastroesophageal reflux disease]] | |||
| prevention = [[Prophylactic gastrectomy]], regular [[endoscopic surveillance]] | |||
| treatment = [[Surgery]], [[chemotherapy]], [[radiation therapy]] | |||
| medication = [[Chemotherapy drugs]] | |||
| prognosis = Variable, depends on stage at diagnosis | |||
| frequency = Rare | |||
| deaths = High mortality if untreated | |||
}} | |||
'''Hereditary Diffuse Gastric Cancer''' (HDGC) is a form of [[stomach cancer]] that is passed down through families. This condition is characterized by the development of diffuse-type [[gastric cancer]] at a young age. | '''Hereditary Diffuse Gastric Cancer''' (HDGC) is a form of [[stomach cancer]] that is passed down through families. This condition is characterized by the development of diffuse-type [[gastric cancer]] at a young age. | ||
== Causes == | == Causes == | ||
HDGC is caused by mutations in the [[CDH1]] gene. This gene provides instructions for making a protein that helps cells stick together and is essential for the normal structure and function of [[tissues]] and [[organs]]. Mutations in the CDH1 gene disrupt this function, leading to the formation of cancerous tumors. | HDGC is caused by mutations in the [[CDH1]] gene. This gene provides instructions for making a protein that helps cells stick together and is essential for the normal structure and function of [[tissues]] and [[organs]]. Mutations in the CDH1 gene disrupt this function, leading to the formation of cancerous tumors. | ||
== Symptoms == | == Symptoms == | ||
The most common symptom of HDGC is [[abdominal pain]]. Other symptoms may include [[nausea]], [[vomiting]], [[loss of appetite]], and [[weight loss]]. In some cases, individuals with HDGC may not show any symptoms until the disease is advanced. | The most common symptom of HDGC is [[abdominal pain]]. Other symptoms may include [[nausea]], [[vomiting]], [[loss of appetite]], and [[weight loss]]. In some cases, individuals with HDGC may not show any symptoms until the disease is advanced. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of HDGC typically involves a combination of [[genetic testing]], [[endoscopy]], and [[biopsy]]. Genetic testing can identify mutations in the CDH1 gene, while endoscopy and biopsy can confirm the presence of cancerous cells in the stomach. | Diagnosis of HDGC typically involves a combination of [[genetic testing]], [[endoscopy]], and [[biopsy]]. Genetic testing can identify mutations in the CDH1 gene, while endoscopy and biopsy can confirm the presence of cancerous cells in the stomach. | ||
== Treatment == | == Treatment == | ||
Treatment for HDGC often involves surgery to remove the stomach ([[gastrectomy]]). Other treatments may include [[chemotherapy]], [[radiation therapy]], and targeted therapies. | Treatment for HDGC often involves surgery to remove the stomach ([[gastrectomy]]). Other treatments may include [[chemotherapy]], [[radiation therapy]], and targeted therapies. | ||
== Prognosis == | == Prognosis == | ||
The prognosis for individuals with HDGC varies. Early detection and treatment can improve the prognosis, but the overall survival rate is low due to the aggressive nature of this type of cancer. | The prognosis for individuals with HDGC varies. Early detection and treatment can improve the prognosis, but the overall survival rate is low due to the aggressive nature of this type of cancer. | ||
== See Also == | == See Also == | ||
* [[Stomach cancer]] | * [[Stomach cancer]] | ||
* [[Genetic testing]] | * [[Genetic testing]] | ||
| Line 30: | Line 39: | ||
* [[Chemotherapy]] | * [[Chemotherapy]] | ||
* [[Radiation therapy]] | * [[Radiation therapy]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
[[Category:Cancer]] | [[Category:Cancer]] | ||
[[Category:Stomach diseases]] | [[Category:Stomach diseases]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 20:29, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
Philadelphia medical weight loss and Philadelphia sleep clinics
| Hereditary diffuse gastric cancer | |
|---|---|
| |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Stomach pain, nausea, vomiting, weight loss, anemia |
| Complications | Metastasis, malnutrition, anemia |
| Onset | Typically in adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic mutation in the CDH1 gene |
| Risks | Family history of the condition, genetic predisposition |
| Diagnosis | Genetic testing, endoscopy, biopsy |
| Differential diagnosis | Sporadic gastric cancer, Peptic ulcer disease, Gastroesophageal reflux disease |
| Prevention | Prophylactic gastrectomy, regular endoscopic surveillance |
| Treatment | Surgery, chemotherapy, radiation therapy |
| Medication | Chemotherapy drugs |
| Prognosis | Variable, depends on stage at diagnosis |
| Frequency | Rare |
| Deaths | High mortality if untreated |
Hereditary Diffuse Gastric Cancer (HDGC) is a form of stomach cancer that is passed down through families. This condition is characterized by the development of diffuse-type gastric cancer at a young age.
Causes[edit]
HDGC is caused by mutations in the CDH1 gene. This gene provides instructions for making a protein that helps cells stick together and is essential for the normal structure and function of tissues and organs. Mutations in the CDH1 gene disrupt this function, leading to the formation of cancerous tumors.
Symptoms[edit]
The most common symptom of HDGC is abdominal pain. Other symptoms may include nausea, vomiting, loss of appetite, and weight loss. In some cases, individuals with HDGC may not show any symptoms until the disease is advanced.
Diagnosis[edit]
Diagnosis of HDGC typically involves a combination of genetic testing, endoscopy, and biopsy. Genetic testing can identify mutations in the CDH1 gene, while endoscopy and biopsy can confirm the presence of cancerous cells in the stomach.
Treatment[edit]
Treatment for HDGC often involves surgery to remove the stomach (gastrectomy). Other treatments may include chemotherapy, radiation therapy, and targeted therapies.
Prognosis[edit]
The prognosis for individuals with HDGC varies. Early detection and treatment can improve the prognosis, but the overall survival rate is low due to the aggressive nature of this type of cancer.
