CDH1

CDH1 (also known as E-cadherin) is a gene that provides instructions for making a protein that is involved in cell adhesion. This protein is found in epithelial tissues, which line the surfaces and cavities of the body. The CDH1 gene is located on the long (q) arm of chromosome 16 at position 22.1.

Function

The CDH1 gene provides instructions for making a protein called E-cadherin. E-cadherin is a type of protein known as a cell adhesion molecule, which helps cells stick together and also helps cells to interact and communicate with each other. E-cadherin is found in cells throughout the body, particularly in epithelial cells, which line the surfaces and cavities of the body.

Clinical significance

Mutations in the CDH1 gene are associated with Hereditary Diffuse Gastric Cancer (HDGC), a rare form of stomach cancer that is inherited in an autosomal dominant manner. Mutations in this gene are also associated with lobular breast cancer, cleft lip and/or cleft palate, and invasive lobular carcinoma.

See also

• Cadherin
• Cell adhesion
• Hereditary Diffuse Gastric Cancer
• Lobular carcinoma

External links

• CDH1 at Genetics Home Reference
• CDH1 at National Center for Biotechnology Information

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