Isodisomy: Difference between revisions
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{{Infobox medical condition | |||
| name = Isodisomy | |||
| synonyms = Uniparental isodisomy | |||
| field = [[Medical genetics]] | |||
| symptoms = [[Developmental delay]], [[growth abnormalities]], [[congenital anomalies]] | |||
| complications = [[Genetic disorders]] | |||
| onset = [[Prenatal]] | |||
| duration = [[Lifelong]] | |||
| causes = [[Uniparental disomy]], [[nondisjunction]] | |||
| risks = [[Advanced maternal age]], [[assisted reproductive technology]] | |||
| diagnosis = [[Genetic testing]], [[karyotyping]] | |||
| differential = [[Heterodisomy]], [[trisomy]] | |||
| treatment = [[Symptomatic treatment]], [[genetic counseling]] | |||
| prognosis = Varies depending on associated conditions | |||
| frequency = Rare | |||
}} | |||
'''Isodisomy''' is a type of [[Uniparental disomy|uniparental disomy]] where two copies of a [[chromosome]] or part of a chromosome are inherited from one parent. This can occur as a result of [[meiosis|meiotic]] non-disjunction or post-zygotic chromosomal duplication. Isodisomy can lead to a number of genetic disorders, depending on the specific chromosomes involved. | '''Isodisomy''' is a type of [[Uniparental disomy|uniparental disomy]] where two copies of a [[chromosome]] or part of a chromosome are inherited from one parent. This can occur as a result of [[meiosis|meiotic]] non-disjunction or post-zygotic chromosomal duplication. Isodisomy can lead to a number of genetic disorders, depending on the specific chromosomes involved. | ||
==Causes== | ==Causes== | ||
Isodisomy can occur as a result of two main processes: meiotic non-disjunction and post-zygotic chromosomal duplication. | Isodisomy can occur as a result of two main processes: meiotic non-disjunction and post-zygotic chromosomal duplication. | ||
In [[meiosis|meiotic]] non-disjunction, both copies of a chromosome from one parent are passed on to the offspring. This can occur in either the first or second division of meiosis. | In [[meiosis|meiotic]] non-disjunction, both copies of a chromosome from one parent are passed on to the offspring. This can occur in either the first or second division of meiosis. | ||
Post-zygotic chromosomal duplication occurs after fertilization, when a single copy of a chromosome duplicates itself to produce two identical copies. | Post-zygotic chromosomal duplication occurs after fertilization, when a single copy of a chromosome duplicates itself to produce two identical copies. | ||
==Genetic Disorders== | ==Genetic Disorders== | ||
Isodisomy can lead to a number of genetic disorders, depending on the specific chromosomes involved. These can include [[Prader-Willi syndrome]], [[Angelman syndrome]], and [[Beckwith-Wiedemann syndrome]], among others. | Isodisomy can lead to a number of genetic disorders, depending on the specific chromosomes involved. These can include [[Prader-Willi syndrome]], [[Angelman syndrome]], and [[Beckwith-Wiedemann syndrome]], among others. | ||
In these disorders, the presence of two identical copies of a chromosome from one parent leads to an imbalance in genetic material, which can disrupt normal development and lead to a range of health problems. | In these disorders, the presence of two identical copies of a chromosome from one parent leads to an imbalance in genetic material, which can disrupt normal development and lead to a range of health problems. | ||
==See Also== | ==See Also== | ||
* [[Uniparental disomy]] | * [[Uniparental disomy]] | ||
* [[Genetic disorder]] | * [[Genetic disorder]] | ||
* [[Chromosome]] | * [[Chromosome]] | ||
* [[Meiosis]] | * [[Meiosis]] | ||
==References== | ==References== | ||
<references /> | <references /> | ||
[[Category:Genetics]] | [[Category:Genetics]] | ||
[[Category:Chromosomes]] | [[Category:Chromosomes]] | ||
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Latest revision as of 23:18, 3 April 2025
| Isodisomy | |
|---|---|
| Synonyms | Uniparental isodisomy |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Developmental delay, growth abnormalities, congenital anomalies |
| Complications | Genetic disorders |
| Onset | Prenatal |
| Duration | Lifelong |
| Types | N/A |
| Causes | Uniparental disomy, nondisjunction |
| Risks | Advanced maternal age, assisted reproductive technology |
| Diagnosis | Genetic testing, karyotyping |
| Differential diagnosis | Heterodisomy, trisomy |
| Prevention | N/A |
| Treatment | Symptomatic treatment, genetic counseling |
| Medication | N/A |
| Prognosis | Varies depending on associated conditions |
| Frequency | Rare |
| Deaths | N/A |
Isodisomy is a type of uniparental disomy where two copies of a chromosome or part of a chromosome are inherited from one parent. This can occur as a result of meiotic non-disjunction or post-zygotic chromosomal duplication. Isodisomy can lead to a number of genetic disorders, depending on the specific chromosomes involved.
Causes[edit]
Isodisomy can occur as a result of two main processes: meiotic non-disjunction and post-zygotic chromosomal duplication. In meiotic non-disjunction, both copies of a chromosome from one parent are passed on to the offspring. This can occur in either the first or second division of meiosis. Post-zygotic chromosomal duplication occurs after fertilization, when a single copy of a chromosome duplicates itself to produce two identical copies.
Genetic Disorders[edit]
Isodisomy can lead to a number of genetic disorders, depending on the specific chromosomes involved. These can include Prader-Willi syndrome, Angelman syndrome, and Beckwith-Wiedemann syndrome, among others. In these disorders, the presence of two identical copies of a chromosome from one parent leads to an imbalance in genetic material, which can disrupt normal development and lead to a range of health problems.
See Also[edit]
References[edit]
<references />
