Cloxestradiol acetate: Difference between revisions
CSV import |
CSV import Tags: mobile edit mobile web edit |
||
| Line 1: | Line 1: | ||
{{Short description|A synthetic estrogen}} | |||
{{Drugbox | |||
| image = Cloxestradiol_acetate.svg | |||
| image_size = 250px | |||
| image_alt = Chemical structure of Cloxestradiol acetate | |||
}} | |||
'''Cloxestradiol acetate''' is a synthetic [[estrogen]] that has been studied for its potential use in [[hormone replacement therapy]] and other medical applications. It is an [[acetate ester]] of [[cloxestradiol]], which is a derivative of [[estradiol]], the primary female [[sex hormone]]. | |||
Cloxestradiol acetate is | |||
== | ==Chemical structure and properties== | ||
[[File:Cloxestradiol_acetate.svg|thumb|right|Chemical structure of Cloxestradiol acetate]] | |||
Cloxestradiol acetate is characterized by its unique chemical structure, which includes a [[chloro]] group and an [[acetate]] ester. This modification enhances its [[lipophilicity]], allowing for better absorption and a longer duration of action compared to [[estradiol]]. The presence of the chloro group also influences its [[binding affinity]] to [[estrogen receptors]]. | |||
== | ==Pharmacology== | ||
Cloxestradiol acetate | Cloxestradiol acetate acts primarily as an [[agonist]] of the [[estrogen receptor]]. Upon administration, it is metabolized into cloxestradiol, which then exerts estrogenic effects in target tissues. These effects include the regulation of [[gene expression]] and modulation of [[cell proliferation]] in estrogen-responsive tissues such as the [[breast]], [[uterus]], and [[bone]]. | ||
== | ===Mechanism of action=== | ||
The mechanism of action of cloxestradiol acetate involves its conversion to cloxestradiol, which binds to estrogen receptors in the cell nucleus. This binding initiates a cascade of events leading to the transcription of estrogen-responsive genes. These genes are involved in various physiological processes, including the maintenance of [[bone density]], regulation of the [[menstrual cycle]], and development of secondary sexual characteristics. | |||
== | ==Medical uses== | ||
Cloxestradiol acetate has been investigated for use in [[hormone replacement therapy]] (HRT) for [[postmenopausal]] women. It may help alleviate symptoms associated with [[menopause]], such as [[hot flashes]], [[vaginal atrophy]], and [[osteoporosis]]. However, its clinical use is limited, and it is not widely available as a therapeutic agent. | |||
== | ==Side effects== | ||
As with other estrogens, cloxestradiol acetate may cause side effects, including [[nausea]], [[breast tenderness]], and [[headaches]]. Long-term use of estrogens has been associated with an increased risk of [[thromboembolic events]], [[breast cancer]], and [[endometrial cancer]]. | |||
[[ | ==Related pages== | ||
[[ | * [[Estradiol]] | ||
[[ | * [[Estrogen receptor]] | ||
* [[Hormone replacement therapy]] | |||
* [[Synthetic estrogens]] | |||
[[Category:Synthetic estrogens]] | |||
[[Category:Hormone replacement therapy]] | |||
Latest revision as of 05:36, 16 February 2025
A synthetic estrogen
| Cloxestradiol acetate | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Cloxestradiol acetate is a synthetic estrogen that has been studied for its potential use in hormone replacement therapy and other medical applications. It is an acetate ester of cloxestradiol, which is a derivative of estradiol, the primary female sex hormone.
Chemical structure and properties[edit]
Cloxestradiol acetate is characterized by its unique chemical structure, which includes a chloro group and an acetate ester. This modification enhances its lipophilicity, allowing for better absorption and a longer duration of action compared to estradiol. The presence of the chloro group also influences its binding affinity to estrogen receptors.
Pharmacology[edit]
Cloxestradiol acetate acts primarily as an agonist of the estrogen receptor. Upon administration, it is metabolized into cloxestradiol, which then exerts estrogenic effects in target tissues. These effects include the regulation of gene expression and modulation of cell proliferation in estrogen-responsive tissues such as the breast, uterus, and bone.
Mechanism of action[edit]
The mechanism of action of cloxestradiol acetate involves its conversion to cloxestradiol, which binds to estrogen receptors in the cell nucleus. This binding initiates a cascade of events leading to the transcription of estrogen-responsive genes. These genes are involved in various physiological processes, including the maintenance of bone density, regulation of the menstrual cycle, and development of secondary sexual characteristics.
Medical uses[edit]
Cloxestradiol acetate has been investigated for use in hormone replacement therapy (HRT) for postmenopausal women. It may help alleviate symptoms associated with menopause, such as hot flashes, vaginal atrophy, and osteoporosis. However, its clinical use is limited, and it is not widely available as a therapeutic agent.
Side effects[edit]
As with other estrogens, cloxestradiol acetate may cause side effects, including nausea, breast tenderness, and headaches. Long-term use of estrogens has been associated with an increased risk of thromboembolic events, breast cancer, and endometrial cancer.
