Nealbarbital: Difference between revisions

Nealbarbital
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Latest revision as of 10:40, 15 February 2025

A barbiturate derivative used in medicine

Nealbarbital is a barbiturate derivative that has been used in the field of medicine for its sedative and hypnotic properties. It is a central nervous system depressant that works by enhancing the activity of the neurotransmitter gamma-aminobutyric acid (GABA).

Pharmacology[edit]

Nealbarbital acts on the GABA_A receptor, increasing the duration of chloride channel opening and thus enhancing the inhibitory effect of GABA in the central nervous system. This results in a calming effect, making it useful for treating conditions such as insomnia and anxiety.

Medical Uses[edit]

Nealbarbital has been used primarily as a sedative and hypnotic agent. It is prescribed for short-term management of insomnia and for preoperative sedation. Due to its potential for dependence and tolerance, its use is generally limited to short durations.

Side Effects[edit]

Common side effects of Nealbarbital include drowsiness, dizziness, and headache. More serious side effects can include respiratory depression, hypotension, and allergic reactions. Long-term use can lead to dependence and withdrawal symptoms.

History[edit]

Nealbarbital was first synthesized in the early 20th century as part of the development of barbiturates for medical use. It was introduced into clinical practice as a safer alternative to earlier sedatives.

Chemical Properties[edit]

Nealbarbital is a barbiturate with a chemical structure that includes a pyrimidine ring. Its molecular formula is C₁₂H₁₄N₂O₃.

Related pages[edit]

@@ Line 1: / Line 1: @@
-'''Nealbarbital''' is a [[barbiturate]] derivative that was first synthesized in the early 20th century. It is a central nervous system depressant with sedative and hypnotic properties.
+{{Short description|A barbiturate derivative used in medicine}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 123456789
+| image = Nealbarbital.svg
+| image_size = 200px
+| image_alt = Structural formula of Nealbarbital
+| image_caption = Chemical structure of Nealbarbital
+}}
-== History ==
+'''Nealbarbital''' is a [[barbiturate]] derivative that has been used in the field of [[medicine]] for its [[sedative]] and [[hypnotic]] properties. It is a [[central nervous system]] [[depressant]] that works by enhancing the activity of the [[neurotransmitter]] [[gamma-aminobutyric acid]] (GABA).
-Nealbarbital was first synthesized in the early 20th century as part of a series of barbiturates, a class of drugs that were widely used for their sedative and hypnotic effects. The [[barbiturates]] were first discovered in 1864 and were used extensively in the first half of the 20th century for the treatment of insomnia, anxiety, and seizure disorders.
+==Pharmacology==
+Nealbarbital acts on the [[GABA_A receptor]], increasing the duration of [[chloride]] channel opening and thus enhancing the inhibitory effect of GABA in the [[central nervous system]]. This results in a calming effect, making it useful for treating conditions such as [[insomnia]] and [[anxiety]].
-== Pharmacology ==
+==Medical Uses==
+Nealbarbital has been used primarily as a [[sedative]] and [[hypnotic]] agent. It is prescribed for short-term management of [[insomnia]] and for preoperative sedation. Due to its potential for [[dependence]] and [[tolerance]], its use is generally limited to short durations.
-Like other barbiturates, Nealbarbital works by increasing the activity of the inhibitory neurotransmitter [[GABA]] in the brain. This results in a decrease in nerve cell activity, leading to sedation and a decrease in anxiety.
+==Side Effects==
+Common side effects of Nealbarbital include [[drowsiness]], [[dizziness]], and [[headache]]. More serious side effects can include [[respiratory depression]], [[hypotension]], and [[allergic reactions]]. Long-term use can lead to [[dependence]] and [[withdrawal symptoms]].
-== Medical Uses ==
+==History==
+Nealbarbital was first synthesized in the early 20th century as part of the development of [[barbiturates]] for medical use. It was introduced into clinical practice as a safer alternative to earlier [[sedatives]].
-Nealbarbital has been used for the treatment of insomnia and anxiety. It has also been used as a premedication for surgery to reduce anxiety and induce sedation. However, due to the risk of dependence and the development of more effective and safer drugs, it is no longer commonly used.
+==Chemical Properties==
+[[File:Nealbarbital.svg|thumb|right|Chemical structure of Nealbarbital]]
+Nealbarbital is a [[barbiturate]] with a chemical structure that includes a [[pyrimidine]] ring. Its molecular formula is C<sub>12</sub>H<sub>14</sub>N<sub>2</sub>O<sub>3</sub>.
-== Side Effects and Risks ==
+==Related pages==
+* [[Barbiturate]]
-Common side effects of Nealbarbital include drowsiness, dizziness, and impaired coordination. More serious side effects can include respiratory depression, dependence, and withdrawal symptoms upon discontinuation.
+* [[Sedative]]
+* [[Hypnotic]]
-Due to the risk of dependence and the availability of safer alternatives, Nealbarbital and other barbiturates are now rarely used. They are considered drugs of last resort for the treatment of insomnia and anxiety.
+* [[GABA_A receptor]]
-== See Also ==
-* [[Barbiturates]]
-* [[GABA]]
-* [[Insomnia]]
-* [[Anxiety]]
 [[Category:Barbiturates]]
-[[Category:GABA modulators]]
+[[Category:Sedatives]]
 [[Category:Hypnotics]]
-[[Category:Sedatives]]
-{{Pharma-stub}}