Butonitazene: Difference between revisions

Butonitazene
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Latest revision as of 03:40, 13 February 2025

A synthetic opioid analgesic

Butonitazene is a synthetic opioid analgesic that belongs to the benzimidazole family of compounds. It is structurally related to other opioids such as etazene and metonitazene. Butonitazene is known for its potent analgesic effects, which are mediated through its action as an agonist at the mu-opioid receptor.

Chemical structure and properties[edit]

Butonitazene is characterized by its complex chemical structure, which includes a benzimidazole core. The chemical formula of Butonitazene is C₂₃H₃₀N₂O₂. The presence of the diethylaminoethyl group and the phenylpiperidine moiety are significant for its pharmacological activity.

Pharmacology[edit]

Butonitazene acts primarily as a mu-opioid receptor agonist. This receptor is part of the opioid receptor family, which also includes the delta-opioid receptor and the kappa-opioid receptor. Activation of the mu-opioid receptor by Butonitazene leads to analgesia, euphoria, and respiratory depression, which are common effects associated with opioid use.

Medical use[edit]

Butonitazene has been investigated for its potential use as an analgesic in clinical settings. However, due to its potency and the risk of adverse effects such as respiratory depression, its use is limited and it is not widely available for medical use.

Adverse effects[edit]

The adverse effects of Butonitazene are similar to those of other opioids. These include:

Respiratory depression
Sedation
Nausea and vomiting
Constipation
Risk of dependence and addiction

Legal status[edit]

Due to its potential for abuse and addiction, Butonitazene is classified as a controlled substance in many countries. Its legal status varies, and it is important to consult local regulations regarding its use and distribution.

Related pages[edit]

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-'''Butonitazene''' is a potent [[opioid]] analgesic drug related to [[etorphine]] and [[carfentanil]], from the [[benzimidazole]] family of opioids. It was first reported in 1956 and subsequently marketed for human use under the brand name Moradol, but was withdrawn from market use due to problems with toxicity and dependence.
+{{Short description|A synthetic opioid analgesic}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 477002123
+| image = Butonitazine.svg
+| image_size = 200px
+| IUPAC_name = 1-(2-(diethylamino)ethyl)-4-phenylpiperidine-4-carboxylic acid ethyl ester
+}}
+'''Butonitazene''' is a synthetic opioid analgesic that belongs to the benzimidazole family of compounds. It is structurally related to other opioids such as [[etazene]] and [[metonitazene]]. Butonitazene is known for its potent analgesic effects, which are mediated through its action as an agonist at the [[mu-opioid receptor]].
+==Chemical structure and properties==
+[[File:Butonitazine.svg|thumb|right|Chemical structure of Butonitazene]]
+Butonitazene is characterized by its complex chemical structure, which includes a benzimidazole core. The chemical formula of Butonitazene is C<sub>23</sub>H<sub>30</sub>N<sub>2</sub>O<sub>2</sub>. The presence of the diethylaminoethyl group and the phenylpiperidine moiety are significant for its pharmacological activity.
 ==Pharmacology==
-Butonitazene is an [[opioid receptor]] agonist that is selective for the μ-opioid receptor. It has a high affinity for this receptor and is believed to act primarily by stimulating it, although it also has some affinity for the δ and κ receptors. The exact mechanism of action is not fully understood, but it is believed to involve inhibition of the reuptake of [[norepinephrine]] and [[serotonin]], which can increase their levels in the brain and contribute to the drug's analgesic effects.
+Butonitazene acts primarily as a [[mu-opioid receptor]] agonist. This receptor is part of the [[opioid receptor]] family, which also includes the [[delta-opioid receptor]] and the [[kappa-opioid receptor]]. Activation of the mu-opioid receptor by Butonitazene leads to analgesia, euphoria, and respiratory depression, which are common effects associated with opioid use.
-==Medical Uses==
+==Medical use==
-Butonitazene was used for the relief of severe pain, such as that associated with [[cancer]] or severe injury. However, due to its high potency and potential for abuse and dependence, it is no longer used in human medicine.
+Butonitazene has been investigated for its potential use as an analgesic in clinical settings. However, due to its potency and the risk of adverse effects such as respiratory depression, its use is limited and it is not widely available for medical use.
-==Side Effects==
+==Adverse effects==
-The side effects of butonitazene are similar to those of other opioids and include [[respiratory depression]], [[constipation]], [[nausea]], [[vomiting]], [[dizziness]], and [[sedation]]. In addition, it can cause severe [[dependence]] and [[withdrawal]] symptoms if used for extended periods.
+The adverse effects of Butonitazene are similar to those of other opioids. These include:
+* Respiratory depression
+* Sedation
+* Nausea and vomiting
+* Constipation
+* Risk of dependence and addiction
-==Legal Status==
+==Legal status==
-Butonitazene is a [[Schedule I]] controlled substance in the United States, meaning it has a high potential for abuse and no accepted medical use. It is also controlled under similar laws in many other countries.
+Due to its potential for abuse and addiction, Butonitazene is classified as a controlled substance in many countries. Its legal status varies, and it is important to consult local regulations regarding its use and distribution.
-==See Also==
+==Related pages==
 * [[Opioid]]
-* [[Opioid receptor]]
+* [[Analgesic]]
+* [[Mu-opioid receptor]]
 * [[Benzimidazole]]
 [[Category:Opioids]]
+[[Category:Synthetic opioids]]
 [[Category:Analgesics]]
-[[Category:Controlled substances]]
-[[Category:Pharmacology]]
-{{pharmacology-stub}}
-{{No image}}