Kappa-opioid receptor

Kappa-opioid receptor

The Kappa-opioid receptor (KOR) is a type of opioid receptor which binds to kappa-opioids such as dynorphin, a natural peptide that is found in the human body. The pronunciation of Kappa-opioid receptor is /ˈkæpə ˈoʊpiɔɪd rɪˈsɛptər/.

Etymology

The term "Kappa-opioid receptor" is derived from the Greek letter kappa (κ), used to denote this type of opioid receptor, and the term "opioid receptor", which refers to a group of G protein-coupled receptors with opioids as ligands.

Function

The Kappa-opioid receptor plays a key role in the regulation of pain, mood, consciousness, motor control, and immune response. Activation of the KOR can lead to analgesic effects, as well as feelings of dysphoria and hallucinations.

Related Terms

• Opioid receptor: A type of protein found on the surface of cells that binds to opioids.
• Dynorphin: An endogenous opioid that acts as a ligand for the KOR.
• G protein-coupled receptors: A large protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways.
• Dysphoria: A profound state of unease or dissatisfaction, often associated with depression.
• Hallucinations: Perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception.

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