25I-NB4OMe: Difference between revisions

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{{Short description|A synthetic psychedelic drug}}
{{DISPLAYTITLE:25I-NB4OMe}}
{{Drugbox
| verifiedrevid = 477318123
| IUPAC_name = 2-(4-Iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine
| image = 25I-NB4OMe.svg
| width = 200px
| legal_status = Uncontrolled
| routes_of_administration = Oral, sublingual, nasal
| CAS_number = 919797-20-9
| PubChem = 44719443
| ChemSpiderID = 23249980
| UNII = 2X9XQ0X4V6
| C=18
| H=22
| I=1
| N=1
| O=3
| smiles = COc1ccccc1CNCCc2cc(OC)c(I)cc2OC
}}


'''25I-NB4OMe''' is a synthetic psychedelic compound that belongs to the [[NBOMe]] class of drugs. It is a derivative of the phenethylamine [[2C-I]] and is known for its potent hallucinogenic effects.  
== Overview ==
'''25I-NB4OMe''' is a synthetic psychedelic compound that belongs to the [[NBOMe]] class of drugs. It is a derivative of the phenethylamine [[2C-I]] and is known for its potent hallucinogenic effects. The compound is primarily used in research settings and has gained attention for its psychoactive properties.


==Chemical structure and properties==
== Chemical Structure ==
25I-NB4OMe is chemically classified as a phenethylamine and a substituted [[amphetamine]]. Its structure includes a 2,5-dimethoxyphenyl ring with an iodine atom at the 4-position, and a 2-methoxybenzyl group attached to the nitrogen atom of the ethylamine chain. This structure is similar to other compounds in the NBOMe series, such as [[25I-NBOMe]] and [[25C-NBOMe]].
[[File:25I-NB4OMe.svg|thumb|right|Chemical structure of 25I-NB4OMe]]
25I-NB4OMe is chemically related to [[2C-I]], with the addition of a methoxy group at the 4-position of the benzyl ring. This modification enhances its affinity for the [[serotonin receptor]]s, particularly the 5-HT2A receptor, which is believed to be responsible for its psychedelic effects.


==Pharmacology==
== Pharmacology ==
25I-NB4OMe acts primarily as a potent agonist of the [[5-HT2A receptor]], which is the primary target for classical psychedelics like [[LSD]] and [[psilocybin]]. The activation of this receptor is responsible for the drug's hallucinogenic effects. The compound is known for its high potency, meaning that very small doses can produce significant effects.
25I-NB4OMe acts as a potent agonist at the 5-HT2A receptor, similar to other compounds in the [[NBOMe]] series. This receptor is a subtype of the [[serotonin receptor]] and plays a crucial role in the modulation of mood, perception, and cognition. The activation of 5-HT2A receptors by 25I-NB4OMe leads to altered sensory perception and hallucinations.


==Effects==
== Effects ==
The effects of 25I-NB4OMe are similar to those of other psychedelics, including altered perception of time and space, visual hallucinations, and changes in thought processes. Users may experience enhanced sensory perception, emotional changes, and a sense of euphoria. However, the drug can also cause adverse effects such as anxiety, paranoia, and confusion.
The effects of 25I-NB4OMe are similar to those of other psychedelic substances, such as [[LSD]] and [[psilocybin]]. Users report visual and auditory hallucinations, altered sense of time, and changes in thought patterns. The onset of effects typically occurs within 30 to 90 minutes after ingestion, with a duration of action lasting 6 to 10 hours.


==Legal status==
== Risks and Safety ==
The legal status of 25I-NB4OMe varies by country. In some jurisdictions, it is classified as a controlled substance, while in others it remains legal or unregulated. Due to its potent effects and potential for harm, many countries have moved to restrict its sale and distribution.
25I-NB4OMe is associated with several risks, particularly when used recreationally. Due to its potency, there is a high risk of overdose, which can lead to severe adverse effects such as [[tachycardia]], [[hypertension]], [[seizures]], and [[psychosis]]. The compound has been linked to several fatalities, underscoring the importance of caution and regulation.


==Safety and risks==
== Legal Status ==
The use of 25I-NB4OMe carries significant risks, particularly due to its high potency and the potential for overdose. Adverse effects can include [[tachycardia]], [[hypertension]], [[hyperthermia]], and [[seizures]]. There have been reports of fatalities associated with its use, often due to misidentification or improper dosing.
The legal status of 25I-NB4OMe varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Researchers must obtain special licenses to study the compound in a laboratory setting.


==Related pages==
== Related Compounds ==
* [[NBOMe series]]
* [[2C-I]]
* [[2C-I]]
* [[25I-NBOMe]]
* [[25C-NBOMe]]
* [[25B-NBOMe]]
== See Also ==
* [[Psychedelic drug]]
* [[Psychedelic drug]]
* [[5-HT2A receptor]]
* [[Serotonin receptor]]
* [[Hallucinogen]]


==Gallery==
== Related Pages ==
<gallery>
* [[NBOMe]]
File:25I-NB4OMe.svg|Chemical structure of 25I-NB4OMe
* [[2C family]]
</gallery>
* [[Psychedelic research]]


[[Category:Psychedelic phenethylamines]]
[[Category:Psychedelic phenethylamines]]
[[Category:Substituted amphetamines]]
[[Category:Serotonin receptor agonists]]
[[Category:Serotonin receptor agonists]]

Latest revision as of 03:36, 13 February 2025


Overview[edit]

25I-NB4OMe is a synthetic psychedelic compound that belongs to the NBOMe class of drugs. It is a derivative of the phenethylamine 2C-I and is known for its potent hallucinogenic effects. The compound is primarily used in research settings and has gained attention for its psychoactive properties.

Chemical Structure[edit]

Chemical structure of 25I-NB4OMe

25I-NB4OMe is chemically related to 2C-I, with the addition of a methoxy group at the 4-position of the benzyl ring. This modification enhances its affinity for the serotonin receptors, particularly the 5-HT2A receptor, which is believed to be responsible for its psychedelic effects.

Pharmacology[edit]

25I-NB4OMe acts as a potent agonist at the 5-HT2A receptor, similar to other compounds in the NBOMe series. This receptor is a subtype of the serotonin receptor and plays a crucial role in the modulation of mood, perception, and cognition. The activation of 5-HT2A receptors by 25I-NB4OMe leads to altered sensory perception and hallucinations.

Effects[edit]

The effects of 25I-NB4OMe are similar to those of other psychedelic substances, such as LSD and psilocybin. Users report visual and auditory hallucinations, altered sense of time, and changes in thought patterns. The onset of effects typically occurs within 30 to 90 minutes after ingestion, with a duration of action lasting 6 to 10 hours.

Risks and Safety[edit]

25I-NB4OMe is associated with several risks, particularly when used recreationally. Due to its potency, there is a high risk of overdose, which can lead to severe adverse effects such as tachycardia, hypertension, seizures, and psychosis. The compound has been linked to several fatalities, underscoring the importance of caution and regulation.

Legal Status[edit]

The legal status of 25I-NB4OMe varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Researchers must obtain special licenses to study the compound in a laboratory setting.

Related Compounds[edit]

See Also[edit]

Related Pages[edit]