LPAR2

LPAR2 or Lysophosphatidic Acid Receptor 2 is a protein that in humans is encoded by the LPAR2 gene. It is a member of the G protein-coupled receptor family and plays a crucial role in several biological processes, including cell proliferation, cell differentiation, and apoptosis.

Function

LPAR2 is a receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. It seems to be coupled to the G protein G(i) and G(q). LPA is an extracellular signaling molecule that has been implicated in various biological processes, including cell migration, cell growth, and cell survival.

Clinical Significance

Alterations in LPAR2 have been associated with various diseases, including cancer, fibrosis, inflammation, and neuropathic pain. In cancer, overexpression of LPAR2 has been observed in several types of tumors, suggesting a role in tumor progression.

See Also

• Lysophospholipid receptor
• G protein-coupled receptor
• Lysophosphatidic acid

References

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External Links

• GeneCards - LPAR2

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