Mazindol: Difference between revisions

Mazindol
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Revision as of 02:51, 11 December 2024

Article about the use of Mazindol in medical treatment

Mazindol is a sympathomimetic amine used primarily as an anorectic agent in the treatment of obesity. It functions as a central nervous system stimulant and is chemically related to amphetamine.

Pharmacology

Mazindol acts as a monoamine reuptake inhibitor, primarily affecting the reuptake of norepinephrine and dopamine. This action increases the levels of these neurotransmitters in the synaptic cleft, leading to increased stimulation of the central nervous system.

Medical Uses

Mazindol is prescribed for short-term management of exogenous obesity. It is typically used in conjunction with a reduced-calorie diet and exercise. The drug is intended for patients with a body mass index (BMI) of 30 or greater, or 27 or greater in the presence of other risk factors such as hypertension, diabetes mellitus, or dyslipidemia.

Side Effects

Common side effects of mazindol include:

Serious side effects may include:

Contraindications

Mazindol is contraindicated in patients with:

History

Mazindol was first introduced in the 1970s and was marketed under various brand names, including Sanorex and Mazanor. Its use has declined due to the availability of newer weight-loss medications and concerns about its side effects.

Regulation

Mazindol is classified as a Schedule IV controlled substance in the United States, indicating it has a low potential for abuse relative to substances in Schedule III.

Research

Recent studies have explored the potential use of mazindol in treating narcolepsy and attention deficit hyperactivity disorder (ADHD), due to its stimulant properties.

Also see

References

External links

@@ Line 1: / Line 1: @@
-[[Image:Mazindol.svg|thumb|right|Chemical structure of Mazindol]]
+{{Short description|Article about the use of Mazindol in medical treatment}}
+{{Drugbox
+| Verifiedfields = changed
+| verifiedrevid = 477241123
+| IUPAC_name = 5-(4-chlorophenyl)-2,3-dihydro-5H-imidazo[2,1-a]isoindol-5-ol
+| image = Mazindol.svg
+| width = 200
+}}
-'''Mazindol''' is a medication primarily used to treat obesity and related conditions. It belongs to the class of drugs known as sympathomimetic amines and acts as an appetite suppressant. Mazindol is commonly prescribed when lifestyle modifications such as diet and exercise alone are not sufficient for weight management.
+'''Mazindol''' is a [[sympathomimetic amine]] used primarily as an [[anorectic]] agent in the treatment of [[obesity]]. It functions as a [[central nervous system]] stimulant and is chemically related to [[amphetamine]].
-== Mechanism of Action ==
+==Pharmacology==
-Mazindol works by stimulating the release of certain neurotransmitters in the brain, such as norepinephrine and dopamine. These neurotransmitters help reduce feelings of hunger and increase the sensation of fullness, which can lead to reduced food intake.
+Mazindol acts as a [[monoamine reuptake inhibitor]], primarily affecting the reuptake of [[norepinephrine]] and [[dopamine]]. This action increases the levels of these neurotransmitters in the synaptic cleft, leading to increased stimulation of the [[central nervous system]].
-== Medical Uses ==
+==Medical Uses==
-Mazindol is primarily prescribed as a short-term treatment for obesity. It is intended for use in combination with a reduced-calorie diet and regular exercise. The medication is not recommended for long-term use, and its effectiveness may decrease over time.
+Mazindol is prescribed for short-term management of exogenous obesity. It is typically used in conjunction with a reduced-calorie diet and exercise. The drug is intended for patients with a body mass index (BMI) of 30 or greater, or 27 or greater in the presence of other risk factors such as [[hypertension]], [[diabetes mellitus]], or [[dyslipidemia]].
-== Side Effects ==
+==Side Effects==
-Common side effects of Mazindol may include:
+Common side effects of mazindol include:
-* Insomnia
+* [[Insomnia]]
-* Nervousness
+* [[Dry mouth]]
-* Increased heart rate
+* [[Constipation]]
-* Elevated blood pressure
+* [[Increased heart rate]]
-* Dry mouth
+* [[Nervousness]]
-* Dizziness
-It is important for patients to be monitored by a healthcare professional while taking Mazindol to manage potential side effects and assess its efficacy.
+Serious side effects may include:
+* [[Hypertension]]
+* [[Palpitations]]
+* [[Psychosis]]
-== Contraindications ==
+==Contraindications==
-Mazindol should not be used in certain medical conditions, including:
+Mazindol is contraindicated in patients with:
-* Heart disease
+* [[Cardiovascular disease]]
-* High blood pressure
+* [[Hyperthyroidism]]
-* Hyperthyroidism
+* [[Glaucoma]]
-* Glaucoma
+* History of [[drug abuse]]
-* History of substance abuse
-{{stub}}
+==History==
-[[Category:Pharmaceuticals]]
+Mazindol was first introduced in the 1970s and was marketed under various brand names, including Sanorex and Mazanor. Its use has declined due to the availability of newer weight-loss medications and concerns about its side effects.
-[[Category:Obesity]]
+==Regulation==
+Mazindol is classified as a Schedule IV controlled substance in the United States, indicating it has a low potential for abuse relative to substances in Schedule III.
+==Research==
+Recent studies have explored the potential use of mazindol in treating [[narcolepsy]] and [[attention deficit hyperactivity disorder]] (ADHD), due to its stimulant properties.
+==Also see==
+* [[Obesity treatment]]
+* [[Anorectic]]
+* [[Central nervous system stimulant]]
+* [[Monoamine reuptake inhibitor]]
+==References==
+{{Reflist}}
+==External links==
+* [https://www.drugs.com/mazindol.html Drugs.com: Mazindol]
+* [https://www.ncbi.nlm.nih.gov/pubmed/?term=mazindol PubMed: Mazindol]
+[[Category:Anorectics]]
+[[Category:Sympathomimetic amines]]
+[[Category:Central nervous system stimulants]]