Bromazepam: Difference between revisions

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'''Bromazepam''' is a [[benzodiazepine]] derivative drug, patented by Roche in 1963 and developed clinically in the 1970s. It possesses [[anxiolytic]], [[sedative]], [[hypnotic]], [[anticonvulsant]], [[muscle relaxant]] and [[amnesic]] properties. Bromazepam is most commonly used as a short-term treatment for [[anxiety disorders]] and panic attacks.
{{Short description|Benzodiazepine medication}}
{{Drugbox
| verifiedfields = changed
| verifiedrevid = 477002648
| image = Bromazepam.svg
| image2 = Bromazepam-from-xtal-3D-balls.png
| image2_caption = 3D model of Bromazepam
}}
 
'''Bromazepam''' is a [[benzodiazepine]] medication primarily used for the treatment of [[anxiety]] and [[insomnia]]. It is known for its calming effects and is often prescribed to alleviate symptoms of anxiety disorders. Bromazepam is marketed under various brand names, including Lexotan and Lexotanil.


==Pharmacology==
==Pharmacology==
Bromazepam binds to the [[GABA_A receptor]], causing a conformational change and increasing inhibitory effects of [[GABA]]. Further, bromazepam may inhibit voltage dependent sodium channels to a lesser extent. The half-life of bromazepam is 12-20 hours.
Bromazepam works by enhancing the effect of the neurotransmitter [[gamma-aminobutyric acid]] (GABA) at the [[GABA_A receptor]], which results in sedative, anxiolytic, muscle relaxant, and anticonvulsant properties. This action helps to calm the nervous system and reduce anxiety.


==Medical uses==
==Medical uses==
Bromazepam is indicated for the short-term treatment of [[insomnia]], short-term treatment of anxiety or panic attacks, if a [[benzodiazepine]] is required, and the alleviation of the symptoms of alcohol- and drug-withdrawal.
Bromazepam is primarily prescribed for the short-term relief of severe anxiety, which can be disabling or subjecting the individual to extreme distress. It is also used in the treatment of [[insomnia]] associated with anxiety. Due to its potential for dependence, it is generally recommended for short-term use.


==Side effects==
==Side effects==
Common side effects of bromazepam are similar to those of other benzodiazepines and can include drowsiness, fatigue, light-headedness, and dry mouth. Less common side effects can include [[dysphoria]], changes in libido, and muscle weakness.
Common side effects of bromazepam include drowsiness, dizziness, and fatigue. In some cases, it may cause confusion, ataxia, and impaired coordination. Long-term use can lead to [[tolerance]] and [[dependence]], and abrupt discontinuation may result in withdrawal symptoms.
 
==Synthesis==
[[File:Bromazepam_synthesis.png|Bromazepam synthesis|thumb|right]]
Bromazepam is synthesized through a series of chemical reactions starting from 2-amino-5-bromobenzophenone. The synthesis involves the formation of a diazepine ring, which is characteristic of benzodiazepines.
 
==Brand names==
Bromazepam is marketed under several brand names, including:
* '''Lexotan'''
* '''Lexotanil'''


==Interactions==
[[File:Lexotan.jpg|Lexotan packaging|thumb|left]]
Bromazepam can interact with a number of medications, including other [[CNS depressants]], certain [[antidepressants]], and certain [[antibiotics]]. It is important to consult with a healthcare provider before starting or stopping any medications.
[[File:Lexotanil_6_mg.png|Lexotanil 6 mg tablets|thumb|right]]


==See also==
==Legal status==
Bromazepam is classified as a controlled substance in many countries due to its potential for abuse and dependence. Its legal status varies, and it is available by prescription only in most regions.
 
==Related pages==
* [[Benzodiazepine]]
* [[Benzodiazepine]]
* [[GABA_A receptor]]
* [[Anxiety disorder]]
* [[Anxiety disorder]]
* [[Insomnia]]
* [[Insomnia]]
* [[Gamma-aminobutyric acid]]


[[Category:Benzodiazepines]]
[[Category:Anxiolytics]]
[[Category:Anxiolytics]]
[[Category:Benzodiazepines]]
[[Category:Sedatives]]
[[Category:Hypnotics]]
[[Category:Roche brands]]
 
{{medicine-stub}}
== Bromazepam ==
<gallery>
File:Lexotan.jpg|Lexotan
File:Lexotanil_6_mg.png|Lexotanil 6 mg
File:Bromazepam_synthesis.png|Bromazepam synthesis
</gallery>
<gallery>
File:Bromazepam.svg|Bromazepam chemical structure
File:Bromazepam-from-xtal-3D-balls.png|3D model of Bromazepam
File:Lexotan.jpg|Lexotan packaging
File:Lexotanil_6_mg.png|Lexotanil 6 mg tablets
File:Bromazepam_synthesis.png|Bromazepam synthesis
</gallery>

Latest revision as of 10:48, 23 March 2025

Benzodiazepine medication


Bromazepam
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG


Bromazepam is a benzodiazepine medication primarily used for the treatment of anxiety and insomnia. It is known for its calming effects and is often prescribed to alleviate symptoms of anxiety disorders. Bromazepam is marketed under various brand names, including Lexotan and Lexotanil.

Pharmacology[edit]

Bromazepam works by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor, which results in sedative, anxiolytic, muscle relaxant, and anticonvulsant properties. This action helps to calm the nervous system and reduce anxiety.

Medical uses[edit]

Bromazepam is primarily prescribed for the short-term relief of severe anxiety, which can be disabling or subjecting the individual to extreme distress. It is also used in the treatment of insomnia associated with anxiety. Due to its potential for dependence, it is generally recommended for short-term use.

Side effects[edit]

Common side effects of bromazepam include drowsiness, dizziness, and fatigue. In some cases, it may cause confusion, ataxia, and impaired coordination. Long-term use can lead to tolerance and dependence, and abrupt discontinuation may result in withdrawal symptoms.

Synthesis[edit]

Bromazepam synthesis

Bromazepam is synthesized through a series of chemical reactions starting from 2-amino-5-bromobenzophenone. The synthesis involves the formation of a diazepine ring, which is characteristic of benzodiazepines.

Brand names[edit]

Bromazepam is marketed under several brand names, including:

  • Lexotan
  • Lexotanil
Lexotan packaging
Lexotanil 6 mg tablets

Legal status[edit]

Bromazepam is classified as a controlled substance in many countries due to its potential for abuse and dependence. Its legal status varies, and it is available by prescription only in most regions.

Related pages[edit]