Lipoatrophic diabetes: Difference between revisions
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{{Infobox medical condition | |||
| name = Lipoatrophic diabetes | |||
| synonyms = Lawrence–Seip syndrome, Seip–Lawrence syndrome | |||
| field = [[Endocrinology]] | |||
| symptoms = [[Insulin resistance]], [[hyperglycemia]], [[lipodystrophy]], [[acanthosis nigricans]] | |||
| complications = [[Diabetes mellitus]], [[cardiovascular disease]], [[liver disease]] | |||
| onset = Childhood or adolescence | |||
| duration = Chronic | |||
| causes = Genetic mutations (e.g., [[AGPAT2]], [[BSCL2]]) | |||
| risks = Family history, genetic predisposition | |||
| diagnosis = Clinical evaluation, genetic testing | |||
| differential = [[Type 1 diabetes]], [[Type 2 diabetes]], other forms of [[lipodystrophy]] | |||
| treatment = [[Insulin therapy]], [[metformin]], [[dietary management]], [[leptin replacement therapy]] | |||
| prognosis = Variable, depends on management of complications | |||
| frequency = Rare | |||
}} | |||
'''Lipoatrophic diabetes''' (also known as ''Lawrence Syndrome'') is a rare form of [[diabetes]] characterized by the loss of [[adipose tissue]], insulin resistance, and hypertriglyceridemia. This condition is also associated with [[hepatomegaly]] and [[acanthosis nigricans]]. | '''Lipoatrophic diabetes''' (also known as ''Lawrence Syndrome'') is a rare form of [[diabetes]] characterized by the loss of [[adipose tissue]], insulin resistance, and hypertriglyceridemia. This condition is also associated with [[hepatomegaly]] and [[acanthosis nigricans]]. | ||
== Symptoms == | == Symptoms == | ||
The symptoms of lipoatrophic diabetes include: | The symptoms of lipoatrophic diabetes include: | ||
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* [[Hepatomegaly]] | * [[Hepatomegaly]] | ||
* [[Acanthosis nigricans]] | * [[Acanthosis nigricans]] | ||
== Causes == | == Causes == | ||
The exact cause of lipoatrophic diabetes is unknown. However, it is believed to be associated with [[autoimmune diseases]], [[infections]], and [[genetic disorders]]. | The exact cause of lipoatrophic diabetes is unknown. However, it is believed to be associated with [[autoimmune diseases]], [[infections]], and [[genetic disorders]]. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of lipoatrophic diabetes is based on clinical features, laboratory tests, and imaging studies. Laboratory tests may include [[blood glucose]] levels, [[lipid profile]], and [[liver function tests]]. Imaging studies may include [[ultrasound]] of the liver and [[magnetic resonance imaging]] (MRI) of the abdomen. | Diagnosis of lipoatrophic diabetes is based on clinical features, laboratory tests, and imaging studies. Laboratory tests may include [[blood glucose]] levels, [[lipid profile]], and [[liver function tests]]. Imaging studies may include [[ultrasound]] of the liver and [[magnetic resonance imaging]] (MRI) of the abdomen. | ||
== Treatment == | == Treatment == | ||
Treatment of lipoatrophic diabetes involves managing the symptoms and preventing complications. This may include [[insulin therapy]], [[dietary modifications]], and [[exercise]]. In severe cases, [[liposuction]] or [[fat transplantation]] may be considered. | Treatment of lipoatrophic diabetes involves managing the symptoms and preventing complications. This may include [[insulin therapy]], [[dietary modifications]], and [[exercise]]. In severe cases, [[liposuction]] or [[fat transplantation]] may be considered. | ||
== See also == | == See also == | ||
* [[Diabetes mellitus]] | * [[Diabetes mellitus]] | ||
* [[Lipodystrophy]] | * [[Lipodystrophy]] | ||
* [[Insulin resistance]] | * [[Insulin resistance]] | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:Diabetes]] | [[Category:Diabetes]] | ||
[[Category:Endocrine diseases]] | [[Category:Endocrine diseases]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
{{stub}} | {{stub}} | ||
{{No image}} | |||
Latest revision as of 23:16, 3 April 2025
| Lipoatrophic diabetes | |
|---|---|
| Synonyms | Lawrence–Seip syndrome, Seip–Lawrence syndrome |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Insulin resistance, hyperglycemia, lipodystrophy, acanthosis nigricans |
| Complications | Diabetes mellitus, cardiovascular disease, liver disease |
| Onset | Childhood or adolescence |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic mutations (e.g., AGPAT2, BSCL2) |
| Risks | Family history, genetic predisposition |
| Diagnosis | Clinical evaluation, genetic testing |
| Differential diagnosis | Type 1 diabetes, Type 2 diabetes, other forms of lipodystrophy |
| Prevention | N/A |
| Treatment | Insulin therapy, metformin, dietary management, leptin replacement therapy |
| Medication | N/A |
| Prognosis | Variable, depends on management of complications |
| Frequency | Rare |
| Deaths | N/A |
Lipoatrophic diabetes (also known as Lawrence Syndrome) is a rare form of diabetes characterized by the loss of adipose tissue, insulin resistance, and hypertriglyceridemia. This condition is also associated with hepatomegaly and acanthosis nigricans.
Symptoms[edit]
The symptoms of lipoatrophic diabetes include:
Causes[edit]
The exact cause of lipoatrophic diabetes is unknown. However, it is believed to be associated with autoimmune diseases, infections, and genetic disorders.
Diagnosis[edit]
Diagnosis of lipoatrophic diabetes is based on clinical features, laboratory tests, and imaging studies. Laboratory tests may include blood glucose levels, lipid profile, and liver function tests. Imaging studies may include ultrasound of the liver and magnetic resonance imaging (MRI) of the abdomen.
Treatment[edit]
Treatment of lipoatrophic diabetes involves managing the symptoms and preventing complications. This may include insulin therapy, dietary modifications, and exercise. In severe cases, liposuction or fat transplantation may be considered.
See also[edit]
References[edit]
<references />
