Collagenous colitis: Difference between revisions
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{{Infobox medical condition | {{SI}} | ||
| name = Collagenous colitis | {{Infobox medical condition | ||
| image = | | name = Collagenous colitis | ||
| | | image = [[File:Collagenous_colitis_-_high_mag.jpg|left|thumb|Micrograph of collagenous colitis, showing the characteristic thickened subepithelial collagen band. H&E stain.]] | ||
| | | caption = Micrograph of collagenous colitis | ||
| field = [[Gastroenterology]] | | field = [[Gastroenterology]] | ||
| symptoms = [[Chronic diarrhea]], [[abdominal pain]], [[weight loss]] | |||
| symptoms = | | complications = [[Dehydration]], [[electrolyte imbalance]] | ||
| complications = | | onset = Typically in [[adulthood]] | ||
| onset = | | duration = [[Chronic condition|Chronic]] | ||
| duration = | | causes = Unknown, possibly [[autoimmune disease|autoimmune]] | ||
| | | risks = [[Smoking]], use of [[nonsteroidal anti-inflammatory drug|NSAIDs]], [[proton pump inhibitor|PPIs]] | ||
| causes = | | diagnosis = [[Colonoscopy]] with [[biopsy]] | ||
| risks = | | differential = [[Ulcerative colitis]], [[Crohn's disease]], [[irritable bowel syndrome]] | ||
| diagnosis = | | treatment = [[Budesonide]], [[loperamide]], [[bismuth subsalicylate]] | ||
| differential = | | prognosis = Generally good with treatment | ||
| frequency = 10 per 100,000 people per year | |||
| treatment = | |||
| prognosis = | |||
| frequency = | |||
}} | }} | ||
{{Short description|A type of inflammatory bowel disease}} | |||
'''Collagenous colitis''' is a form of [[inflammatory bowel disease]] characterized by chronic [[diarrhea]] and inflammation of the [[colon]]. It is a type of [[microscopic colitis]], which means that the inflammation is not visible during a colonoscopy and can only be seen under a microscope. | |||
==Pathophysiology== | |||
Collagenous colitis is distinguished by the presence of a thickened layer of [[collagen]] beneath the [[epithelium]] of the colon. This collagen layer is typically more than 10 micrometers thick. The exact cause of collagenous colitis is not well understood, but it is believed to involve an abnormal immune response in the [[gastrointestinal tract]]. | |||
==Symptoms== | |||
The primary symptom of collagenous colitis is chronic, non-bloody [[watery diarrhea]]. Other symptoms may include [[abdominal pain]], [[bloating]], and [[weight loss]]. Some patients may also experience [[fatigue]] and [[dehydration]] due to the persistent diarrhea. | |||
==Diagnosis== | ==Diagnosis== | ||
Diagnosis of collagenous colitis is typically made through a combination of clinical evaluation and [[colonoscopy]] with [[biopsy]]. During a colonoscopy, the colon may appear normal, but a biopsy will reveal the characteristic thickened collagen layer. [[Histopathology]] is essential for confirming the diagnosis. | |||
==Treatment== | ==Treatment== | ||
Treatment for collagenous colitis often begins with lifestyle and dietary changes, such as avoiding [[caffeine]] and [[lactose]]. Medications may include [[antidiarrheal]] agents, [[anti-inflammatory]] drugs, and [[immunosuppressive]] therapies. In some cases, [[budesonide]], a corticosteroid, is used to reduce inflammation. | |||
==Prognosis== | |||
The prognosis for collagenous colitis is generally good, with many patients responding well to treatment. However, the condition can be chronic and may require long-term management. Relapses are common, and ongoing monitoring by a healthcare provider is often necessary. | |||
==Epidemiology== | |||
Collagenous colitis is more common in [[middle-aged]] and [[elderly]] individuals, with a higher prevalence in [[women]] than in [[men]]. The exact prevalence is not well established, but it is considered a rare condition. | |||
==See also== | ==See also== | ||
*[[ | * [[Microscopic colitis]] | ||
*[[Lymphocytic colitis]] | * [[Lymphocytic colitis]] | ||
*[[Inflammatory bowel disease]] | * [[Inflammatory bowel disease]] | ||
[[Category:Inflammatory bowel disease]] | |||
[[Category:Gastroenterology]] | |||
[[Category: | |||
[[Category: | |||
Latest revision as of 02:10, 5 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Collagenous colitis | |
|---|---|
 | |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Chronic diarrhea, abdominal pain, weight loss |
| Complications | Dehydration, electrolyte imbalance |
| Onset | Typically in adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Unknown, possibly autoimmune |
| Risks | Smoking, use of NSAIDs, PPIs |
| Diagnosis | Colonoscopy with biopsy |
| Differential diagnosis | Ulcerative colitis, Crohn's disease, irritable bowel syndrome |
| Prevention | N/A |
| Treatment | Budesonide, loperamide, bismuth subsalicylate |
| Medication | N/A |
| Prognosis | Generally good with treatment |
| Frequency | 10 per 100,000 people per year |
| Deaths | N/A |
A type of inflammatory bowel disease
Collagenous colitis is a form of inflammatory bowel disease characterized by chronic diarrhea and inflammation of the colon. It is a type of microscopic colitis, which means that the inflammation is not visible during a colonoscopy and can only be seen under a microscope.
Pathophysiology[edit]
Collagenous colitis is distinguished by the presence of a thickened layer of collagen beneath the epithelium of the colon. This collagen layer is typically more than 10 micrometers thick. The exact cause of collagenous colitis is not well understood, but it is believed to involve an abnormal immune response in the gastrointestinal tract.
Symptoms[edit]
The primary symptom of collagenous colitis is chronic, non-bloody watery diarrhea. Other symptoms may include abdominal pain, bloating, and weight loss. Some patients may also experience fatigue and dehydration due to the persistent diarrhea.
Diagnosis[edit]
Diagnosis of collagenous colitis is typically made through a combination of clinical evaluation and colonoscopy with biopsy. During a colonoscopy, the colon may appear normal, but a biopsy will reveal the characteristic thickened collagen layer. Histopathology is essential for confirming the diagnosis.
Treatment[edit]
Treatment for collagenous colitis often begins with lifestyle and dietary changes, such as avoiding caffeine and lactose. Medications may include antidiarrheal agents, anti-inflammatory drugs, and immunosuppressive therapies. In some cases, budesonide, a corticosteroid, is used to reduce inflammation.
Prognosis[edit]
The prognosis for collagenous colitis is generally good, with many patients responding well to treatment. However, the condition can be chronic and may require long-term management. Relapses are common, and ongoing monitoring by a healthcare provider is often necessary.
Epidemiology[edit]
Collagenous colitis is more common in middle-aged and elderly individuals, with a higher prevalence in women than in men. The exact prevalence is not well established, but it is considered a rare condition.
