Aschoff body: Difference between revisions
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{{SI}} | |||
{{Infobox medical condition | |||
| name = Aschoff body | |||
| image = [[File:Rheumatic_heart_disease_-_3b_-_very_high_mag.jpg|250px]] | |||
| caption = Histological image showing an Aschoff body in rheumatic heart disease | |||
| field = [[Cardiology]], [[Pathology]] | |||
| synonyms = Aschoff nodule | |||
| diseasesdb = | |||
| omim = | |||
| medlineplus = | |||
| eMedicineSubj = | |||
| eMedicineTopic = | |||
| meshid = D001195 | |||
| specialty = [[Cardiology]], [[Rheumatology]] | |||
| symptoms = Inflammation of the heart tissue, [[myocarditis]] | |||
| complications = [[Rheumatic heart disease]], [[heart failure]] | |||
| onset = Typically occurs in [[acute rheumatic fever]] | |||
| duration = Can persist if not treated | |||
| causes = [[Rheumatic fever]] | |||
| risks = Previous [[streptococcal infection]] | |||
| diagnosis = [[Histopathology]] | |||
| differential = [[Infective endocarditis]], [[myocardial infarction]] | |||
| prevention = Treatment of [[streptococcal infections]] | |||
| treatment = [[Anti-inflammatory medication]], [[antibiotics]] | |||
| prognosis = Variable, depends on severity and treatment | |||
| frequency = Rare in developed countries, more common in developing regions | |||
}} | |||
'''Aschoff body''' is a [[histopathological]] finding, typically associated with [[rheumatic fever]]. It is named after the German pathologist [[Karl Aschoff]], who first described it in 1904. | '''Aschoff body''' is a [[histopathological]] finding, typically associated with [[rheumatic fever]]. It is named after the German pathologist [[Karl Aschoff]], who first described it in 1904. | ||
==Definition== | ==Definition== | ||
An Aschoff body is a [[granuloma]] that forms in the [[connective tissue]] of the heart in response to [[rheumatic fever]]. It is characterized by central necrosis surrounded by [[macrophages]], including distinctive multinucleated macrophages known as Aschoff cells. | An Aschoff body is a [[granuloma]] that forms in the [[connective tissue]] of the heart in response to [[rheumatic fever]]. It is characterized by central necrosis surrounded by [[macrophages]], including distinctive multinucleated macrophages known as Aschoff cells. | ||
==Pathogenesis== | ==Pathogenesis== | ||
[[Rheumatic fever]] is an inflammatory disease that can develop as a complication of inadequately treated [[streptococcal pharyngitis]] or [[scarlet fever]]. The body's immune response to the [[Streptococcus]] bacteria leads to inflammation and the formation of Aschoff bodies in the heart tissue. | [[Rheumatic fever]] is an inflammatory disease that can develop as a complication of inadequately treated [[streptococcal pharyngitis]] or [[scarlet fever]]. The body's immune response to the [[Streptococcus]] bacteria leads to inflammation and the formation of Aschoff bodies in the heart tissue. | ||
==Clinical significance== | ==Clinical significance== | ||
The presence of Aschoff bodies is a key diagnostic feature of rheumatic fever. They are most commonly found in the heart, particularly in the [[myocardium]], but can also occur in other tissues. The formation of Aschoff bodies can lead to [[rheumatic heart disease]], a serious complication of rheumatic fever that can result in permanent damage to the heart valves. | The presence of Aschoff bodies is a key diagnostic feature of rheumatic fever. They are most commonly found in the heart, particularly in the [[myocardium]], but can also occur in other tissues. The formation of Aschoff bodies can lead to [[rheumatic heart disease]], a serious complication of rheumatic fever that can result in permanent damage to the heart valves. | ||
==See also== | ==See also== | ||
* [[Rheumatic fever]] | * [[Rheumatic fever]] | ||
| Line 17: | Line 40: | ||
* [[Streptococcal pharyngitis]] | * [[Streptococcal pharyngitis]] | ||
* [[Scarlet fever]] | * [[Scarlet fever]] | ||
[[Category:Pathology]] | [[Category:Pathology]] | ||
[[Category:Cardiology]] | [[Category:Cardiology]] | ||
[[Category:Rheumatology]] | [[Category:Rheumatology]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 21:55, 5 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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| Aschoff body | |
|---|---|
| |
| Synonyms | Aschoff nodule |
| Pronounce | N/A |
| Specialty | Cardiology, Rheumatology |
| Symptoms | Inflammation of the heart tissue, myocarditis |
| Complications | Rheumatic heart disease, heart failure |
| Onset | Typically occurs in acute rheumatic fever |
| Duration | Can persist if not treated |
| Types | N/A |
| Causes | Rheumatic fever |
| Risks | Previous streptococcal infection |
| Diagnosis | Histopathology |
| Differential diagnosis | Infective endocarditis, myocardial infarction |
| Prevention | Treatment of streptococcal infections |
| Treatment | Anti-inflammatory medication, antibiotics |
| Medication | N/A |
| Prognosis | Variable, depends on severity and treatment |
| Frequency | Rare in developed countries, more common in developing regions |
| Deaths | N/A |
Aschoff body is a histopathological finding, typically associated with rheumatic fever. It is named after the German pathologist Karl Aschoff, who first described it in 1904.
Definition[edit]
An Aschoff body is a granuloma that forms in the connective tissue of the heart in response to rheumatic fever. It is characterized by central necrosis surrounded by macrophages, including distinctive multinucleated macrophages known as Aschoff cells.
Pathogenesis[edit]
Rheumatic fever is an inflammatory disease that can develop as a complication of inadequately treated streptococcal pharyngitis or scarlet fever. The body's immune response to the Streptococcus bacteria leads to inflammation and the formation of Aschoff bodies in the heart tissue.
Clinical significance[edit]
The presence of Aschoff bodies is a key diagnostic feature of rheumatic fever. They are most commonly found in the heart, particularly in the myocardium, but can also occur in other tissues. The formation of Aschoff bodies can lead to rheumatic heart disease, a serious complication of rheumatic fever that can result in permanent damage to the heart valves.
