Linear IgA bullous dermatosis: Difference between revisions
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{{SI}} | |||
{{Infobox medical condition | |||
| name = Linear IgA bullous dermatosis | |||
| image = [[File:Linear_IgA_bullous_dermatosis.jpg|left|thumb|Linear IgA bullous dermatosis]] | |||
| caption = Linear IgA bullous dermatosis on the skin | |||
| synonyms = Chronic bullous disease of childhood | |||
| field = [[Dermatology]] | |||
| symptoms = [[Blister]]s, [[itching]], [[rash]] | |||
| complications = [[Infection]], [[scarring]] | |||
| onset = Any age, commonly in children | |||
| duration = Chronic | |||
| causes = [[Autoimmune disease]] | |||
| risks = Genetic predisposition, [[medication]]s | |||
| diagnosis = [[Skin biopsy]], [[direct immunofluorescence]] | |||
| differential = [[Bullous pemphigoid]], [[Dermatitis herpetiformis]] | |||
| treatment = [[Dapsone]], [[corticosteroids]] | |||
| medication = [[Dapsone]], [[prednisone]] | |||
| frequency = Rare | |||
}} | |||
[[File:IgA_bullous_dermatosis.jpg|IgA Bullous Dermatosis|thumb|left]] | |||
'''Linear IgA bullous dermatosis''' (LABD) is a rare, chronic [[autoimmune disease|autoimmune]] [[skin disease|skin disorder]] characterized by blisters on the skin and mucous membranes. The disease is named for the linear deposition of [[Immunoglobulin A|IgA]] antibodies in the skin. | '''Linear IgA bullous dermatosis''' (LABD) is a rare, chronic [[autoimmune disease|autoimmune]] [[skin disease|skin disorder]] characterized by blisters on the skin and mucous membranes. The disease is named for the linear deposition of [[Immunoglobulin A|IgA]] antibodies in the skin. | ||
== Signs and Symptoms == | == Signs and Symptoms == | ||
Patients with LABD often present with tense blisters and urticarial plaques. The blisters may be filled with clear fluid or blood, and are often surrounded by red, inflamed skin. The blisters can appear anywhere on the body, but are most common on the arms, legs, and torso. Mucous membranes, such as the mouth and genitals, may also be affected. | Patients with LABD often present with tense blisters and urticarial plaques. The blisters may be filled with clear fluid or blood, and are often surrounded by red, inflamed skin. The blisters can appear anywhere on the body, but are most common on the arms, legs, and torso. Mucous membranes, such as the mouth and genitals, may also be affected. | ||
== Causes == | == Causes == | ||
The exact cause of LABD is unknown, but it is thought to be an autoimmune response. This means that the body's immune system mistakenly attacks its own cells. In the case of LABD, the immune system attacks the skin cells, leading to the formation of blisters. | The exact cause of LABD is unknown, but it is thought to be an autoimmune response. This means that the body's immune system mistakenly attacks its own cells. In the case of LABD, the immune system attacks the skin cells, leading to the formation of blisters. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of LABD is typically made through a combination of clinical examination and skin biopsy. The biopsy will show a linear deposition of IgA at the basement membrane zone, which is characteristic of the disease. | Diagnosis of LABD is typically made through a combination of clinical examination and skin biopsy. The biopsy will show a linear deposition of IgA at the basement membrane zone, which is characteristic of the disease. | ||
== Treatment == | == Treatment == | ||
Treatment for LABD typically involves medications to suppress the immune system and reduce inflammation. These may include corticosteroids, dapsone, and other immunosuppressive drugs. | Treatment for LABD typically involves medications to suppress the immune system and reduce inflammation. These may include corticosteroids, dapsone, and other immunosuppressive drugs. | ||
== Prognosis == | == Prognosis == | ||
The prognosis for LABD is generally good, with most patients achieving remission with treatment. However, the disease can be chronic and relapsing, and some patients may experience significant morbidity. | The prognosis for LABD is generally good, with most patients achieving remission with treatment. However, the disease can be chronic and relapsing, and some patients may experience significant morbidity. | ||
== See Also == | == See Also == | ||
* [[Dermatitis herpetiformis]] | * [[Dermatitis herpetiformis]] | ||
* [[Bullous pemphigoid]] | * [[Bullous pemphigoid]] | ||
* [[Pemphigus vulgaris]] | * [[Pemphigus vulgaris]] | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:Skin diseases]] | [[Category:Skin diseases]] | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 04:15, 9 April 2025
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Obesity, Sleep & Internal medicine
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| Linear IgA bullous dermatosis | |
|---|---|
 | |
| Synonyms | Chronic bullous disease of childhood |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Blisters, itching, rash |
| Complications | Infection, scarring |
| Onset | Any age, commonly in children |
| Duration | Chronic |
| Types | N/A |
| Causes | Autoimmune disease |
| Risks | Genetic predisposition, medications |
| Diagnosis | Skin biopsy, direct immunofluorescence |
| Differential diagnosis | Bullous pemphigoid, Dermatitis herpetiformis |
| Prevention | N/A |
| Treatment | Dapsone, corticosteroids |
| Medication | Dapsone, prednisone |
| Prognosis | N/A |
| Frequency | Rare |
| Deaths | N/A |
Linear IgA bullous dermatosis (LABD) is a rare, chronic autoimmune skin disorder characterized by blisters on the skin and mucous membranes. The disease is named for the linear deposition of IgA antibodies in the skin.
Signs and Symptoms[edit]
Patients with LABD often present with tense blisters and urticarial plaques. The blisters may be filled with clear fluid or blood, and are often surrounded by red, inflamed skin. The blisters can appear anywhere on the body, but are most common on the arms, legs, and torso. Mucous membranes, such as the mouth and genitals, may also be affected.
Causes[edit]
The exact cause of LABD is unknown, but it is thought to be an autoimmune response. This means that the body's immune system mistakenly attacks its own cells. In the case of LABD, the immune system attacks the skin cells, leading to the formation of blisters.
Diagnosis[edit]
Diagnosis of LABD is typically made through a combination of clinical examination and skin biopsy. The biopsy will show a linear deposition of IgA at the basement membrane zone, which is characteristic of the disease.
Treatment[edit]
Treatment for LABD typically involves medications to suppress the immune system and reduce inflammation. These may include corticosteroids, dapsone, and other immunosuppressive drugs.
Prognosis[edit]
The prognosis for LABD is generally good, with most patients achieving remission with treatment. However, the disease can be chronic and relapsing, and some patients may experience significant morbidity.
See Also[edit]
References[edit]
<references />
