Pempidine: Difference between revisions
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{{Short description|An article about the drug Pempidine}} | |||
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| image_alt = Structural formula of Pempidine | |||
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'''Pempidine''' is a [[ganglionic blocker]] that was historically used as an [[antihypertensive]] agent. It is a member of the [[piperidine]] class of compounds and functions by inhibiting the transmission of nerve impulses in the [[autonomic nervous system]]. | |||
Pempidine is a [[ | ==Chemical structure and properties== | ||
[[File:Pempidine.svg|thumb|right|200px|Structural formula of Pempidine]] | |||
Pempidine is a [[piperidine]] derivative with the chemical formula C10H19N. It is characterized by a six-membered ring containing five carbon atoms and one nitrogen atom. The structure of pempidine allows it to interact with [[nicotinic acetylcholine receptors]] in the [[autonomic ganglia]], leading to its pharmacological effects. | |||
== | ==Pharmacology== | ||
Pempidine acts as a [[ganglionic blocker]], which means it inhibits the transmission of nerve impulses in the [[autonomic nervous system]]. This action results in a decrease in [[blood pressure]], making it useful in the treatment of [[hypertension]]. However, due to its broad effects on the autonomic nervous system, it can cause a range of side effects, limiting its clinical use. | |||
==Medical uses== | |||
Historically, pempidine was used as an [[antihypertensive]] agent. It was one of the early drugs used to manage high blood pressure by blocking the transmission of nerve signals in the [[autonomic ganglia]]. However, with the development of more selective and better-tolerated antihypertensive agents, the use of pempidine has declined. | |||
== Side | ==Side effects== | ||
The use of pempidine can lead to several side effects due to its non-selective action on the autonomic nervous system. Common side effects include [[dry mouth]], [[constipation]], [[urinary retention]], and [[blurred vision]]. These side effects are a result of the blockade of [[parasympathetic]] ganglia. | |||
==History== | |||
Pempidine was developed in the mid-20th century as part of the search for effective [[antihypertensive]] agents. It was one of the first drugs to demonstrate the potential of ganglionic blockade in the management of high blood pressure. However, its use has largely been replaced by more modern medications with fewer side effects. | |||
== | ==Related pages== | ||
* [[Antihypertensive drug]] | |||
* [[Ganglionic blocker]] | |||
* [[Piperidine]] | |||
[[Category:Antihypertensive agents]] | |||
[[Category:Piperidines]] | |||
[[Category: | |||
[[Category: | |||
Latest revision as of 03:40, 13 February 2025
An article about the drug Pempidine
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Pempidine is a ganglionic blocker that was historically used as an antihypertensive agent. It is a member of the piperidine class of compounds and functions by inhibiting the transmission of nerve impulses in the autonomic nervous system.
Chemical structure and properties[edit]
Pempidine is a piperidine derivative with the chemical formula C10H19N. It is characterized by a six-membered ring containing five carbon atoms and one nitrogen atom. The structure of pempidine allows it to interact with nicotinic acetylcholine receptors in the autonomic ganglia, leading to its pharmacological effects.
Pharmacology[edit]
Pempidine acts as a ganglionic blocker, which means it inhibits the transmission of nerve impulses in the autonomic nervous system. This action results in a decrease in blood pressure, making it useful in the treatment of hypertension. However, due to its broad effects on the autonomic nervous system, it can cause a range of side effects, limiting its clinical use.
Medical uses[edit]
Historically, pempidine was used as an antihypertensive agent. It was one of the early drugs used to manage high blood pressure by blocking the transmission of nerve signals in the autonomic ganglia. However, with the development of more selective and better-tolerated antihypertensive agents, the use of pempidine has declined.
Side effects[edit]
The use of pempidine can lead to several side effects due to its non-selective action on the autonomic nervous system. Common side effects include dry mouth, constipation, urinary retention, and blurred vision. These side effects are a result of the blockade of parasympathetic ganglia.
History[edit]
Pempidine was developed in the mid-20th century as part of the search for effective antihypertensive agents. It was one of the first drugs to demonstrate the potential of ganglionic blockade in the management of high blood pressure. However, its use has largely been replaced by more modern medications with fewer side effects.
