Serotonin-norepinephrine reuptake inhibitors

Serotonin-norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs that treat major depressive disorder, anxiety disorders, obsessive-compulsive disorder, attention-deficit hyperactivity disorder, chronic pain, fibromyalgia and menopausal symptoms.

Pronunciation

Serotonin-norepinephrine reuptake inhibitors: /sɛrəˈtoʊnɪn nɔːrɛpɪˈnɛfrɪn riːˈʌptəkeɪt ɪnˈhɪbɪtərs/

Etymology

The term "Serotonin-norepinephrine reuptake inhibitors" is derived from their mechanism of action. They inhibit the reuptake of the neurotransmitters serotonin and norepinephrine, increasing the levels of these two neurotransmitters in the brain.

Mechanism of action

SNRIs work by inhibiting the reuptake of the neurotransmitters serotonin and norepinephrine in the brain. This results in increased levels of these neurotransmitters in the synaptic cleft, which leads to improved mood.

Related terms

• Selective serotonin reuptake inhibitors (SSRIs)
• Tricyclic antidepressants (TCAs)
• Monoamine oxidase inhibitors (MAOIs)
• Atypical antidepressants

See also

• List of Serotonin-norepinephrine reuptake inhibitors
• Pharmacology
• Psychiatry

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