Selective serotonin reuptake inhibitors
Selective serotonin reuptake inhibitors
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.
Pronunciation
Selective serotonin reuptake inhibitors: /sɪˈlɛktɪv sɛrəˈtoʊnɪn riːˈʌptɪk ɪnˈhɪbɪtərs/
Etymology
The term "Selective serotonin reuptake inhibitors" is derived from the drug's mechanism of action. It selectively inhibits the reuptake of serotonin, a neurotransmitter, in the brain, thereby increasing its availability.
Mechanism of Action
SSRIs work by increasing the amount of serotonin in the brain. They do this by blocking the reuptake of serotonin into the presynaptic cell, increasing the level of serotonin in the synaptic cleft available to bind to the postsynaptic receptor. This results in antidepressant and anxiolytic effects.
Types of SSRIs
There are several types of SSRIs, including fluoxetine, citalopram, sertraline, paroxetine, and escitalopram. Each of these drugs has a slightly different chemical structure and may therefore affect individuals in slightly different ways.
Side Effects
Common side effects of SSRIs include nausea, upset stomach, diarrhea, and sexual problems. More serious side effects can include suicidal thoughts, especially in young people.
Related Terms
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