Tetramethylthiourea

Tetramethylthiourea is a chemical compound with the formula (CH3)4N2S. It is a white crystalline solid that is soluble in water and most organic solvents. Tetramethylthiourea is used as a building block in organic synthesis and as a reagent in the production of various pharmaceuticals.

Structure and Properties

Tetramethylthiourea is a thiourea derivative, which means it contains a thiourea functional group. This group consists of a sulfur atom bonded to two nitrogen atoms and two methyl groups. The sulfur atom in tetramethylthiourea is also bonded to two additional methyl groups, giving the compound its name.

The compound is a white crystalline solid at room temperature. It has a melting point of 104-106 °C and a boiling point of 280 °C. Tetramethylthiourea is soluble in water and most organic solvents, including ethanol, methanol, and acetone.

Synthesis

Tetramethylthiourea can be synthesized by the reaction of methylamine with carbon disulfide in the presence of a base. The reaction proceeds via the formation of a dithiocarbamate intermediate, which is then converted to tetramethylthiourea by reaction with additional methylamine.

Applications

Tetramethylthiourea is used as a building block in organic synthesis. It can act as a nucleophile, reacting with electrophiles to form new carbon-sulfur bonds. This makes it a useful reagent in the synthesis of various pharmaceuticals, including antibiotics and antiviral drugs.

In addition to its use in organic synthesis, tetramethylthiourea is also used as a corrosion inhibitor in the oil and gas industry. It forms a protective layer on the surface of metals, preventing them from reacting with oxygen and other corrosive substances.

Safety

Tetramethylthiourea is considered a hazardous substance. It can cause skin and eye irritation, and prolonged exposure can lead to respiratory problems. It is also harmful if swallowed. Therefore, it should be handled with care, using appropriate personal protective equipment.

See Also

• Thiourea
• Methylamine
• Carbon disulfide

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