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Template:DNA replication

From WikiMD's medical encyclopedia

DNA replication (comparing prokaryotic to eukaryotic)
Initiation
Prokaryotic
(initiation)
* Pre-replication complex
  • dnaC
  • Helicase
    • dnaA
    • dnaB
    • T7
  • Primase
    • dnaG
Eukaryotic
(preparation in
G1 phase
)
* Pre-replication complex
  • Origin recognition complex
    • ORC1
    • ORC2
    • ORC3
    • ORC4
    • ORC5
    • ORC6
  • Cdc6
  • Cdt1
  • Minichromosome maintenance
    • MCM2
    • MCM3
    • MCM4
    • MCM5
    • MCM6
    • MCM7
  • Licensing factor
  • Autonomously replicating sequence
  • Single-strand binding protein
    • SSBP2
    • SSBP3
    • SSBP4
  • RNase H
    • RNASEH1
    • RNASEH2A
  • Helicase: HFM1
  • Primase: PRIM1
  • PRIM2
Both
* Origin of replication/Ori/Replicon
  • Replication fork
    • Lagging and leading strands
  • Okazaki fragments
  • Primer
Replication
Prokaryotic
(elongation)
* DNA polymerase III holoenzyme
    • dnaC
    • dnaE
    • dnaH
    • dnaN
    • dnaQ
    • dnaT
    • dnaX
    • holA
    • holB
    • holC
    • holD
    • holE
  • Replisome
  • DNA ligase
  • DNA clamp
  • Topoisomerase
    • DNA gyrase
  • Prokaryotic DNA polymerase: DNA polymerase I
    • Klenow fragment
Eukaryotic
(synthesis in
S phase
)
* Replication factor C
    • RFC1
  • Flap endonuclease
    • FEN1
  • Topoisomerase
  • Replication protein A
    • RPA1
  • Eukaryotic DNA polymerase:
  • alpha
    • POLA1
    • POLA2
    • PRIM1
    • PRIM2
  • delta
    • POLD1
    • POLD2
    • POLD3
    • POLD4
  • epsilon
    • POLE
    • POLE2
    • POLE3
    • POLE4
  • DNA clamp
    • PCNA
  • Control of chromosome duplication
Both
* Movement: Processivity
  • DNA ligase
Termination
* Telomere: Telomerase
    • TERT
    • TERC
    • DKC1


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