Sertoli cell-only syndrome

Sertoli cell-only syndrome (also known as Germ cell aplasia or Del Castillo syndrome) is a medical condition characterized by the absence of germ cells in the seminiferous tubules of the testes, leading to male infertility.

Pronunciation

The term is pronounced as ser-toh-lee sel ohn-lee sin-drohm.

Etymology

The syndrome is named after the Italian physiologist Enrico Sertoli, who first described the cells in 1865. The term "cell-only" refers to the presence of only Sertoli cells in the seminiferous tubules, with no germ cells.

Definition

Sertoli cell-only syndrome is a condition where the seminiferous tubules of the testes, which are normally responsible for sperm production, contain only Sertoli cells and no germ cells. This results in a lack of sperm production, leading to male infertility.

Symptoms

The primary symptom of Sertoli cell-only syndrome is infertility. Men with this condition may also have low testosterone levels and may experience symptoms such as reduced sexual desire and erectile dysfunction.

Causes

The exact cause of Sertoli cell-only syndrome is unknown. However, it is believed to be due to a combination of genetic and environmental factors. Some studies suggest that mutations in the FSH receptor gene may be involved.

Diagnosis

Diagnosis of Sertoli cell-only syndrome is typically made through a testicular biopsy, which shows the absence of germ cells in the seminiferous tubules.

Treatment

There is currently no cure for Sertoli cell-only syndrome. Treatment is focused on managing symptoms and may include hormone replacement therapy to address low testosterone levels. Assisted reproductive technologies, such as intracytoplasmic sperm injection (ICSI), may be used to help couples conceive.

Related Terms

• Sertoli cells
• Seminiferous tubules
• FSH receptor
• Intracytoplasmic sperm injection

External links

• Medical encyclopedia article on Sertoli cell-only syndrome
• Wikipedia's article - Sertoli cell-only syndrome

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