Rhabdoviridae

From WikiMD's medical encyclopedia

Rhabdoviridae is a family of viruses in the order Mononegavirales. Viruses within this family have a negative-sense single-stranded RNA genome. The viral particles are enveloped and have a bullet shape with a helical symmetry. The family includes the important human pathogen, Rabies virus, which causes the disease rabies.

Taxonomy

The family Rhabdoviridae is divided into 20 genera:

Structure and genome

Rhabdoviridae viruses are enveloped, with bullet shaped geometries. The diameter is around 75 nm. Genomes are linear, around 11-15kb in length. The genome codes for five proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and the RNA dependent RNA polymerase (L).

Replication

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral G glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus replication model. Negative stranded RNA virus transcription, using polymerase stuttering is the method of transcription. The virus exits the host cell by budding, and tubule-guided viral movement. Humans and mammals serve as the natural host.

Diseases

Rhabdoviridae includes several notable pathogens of humans and animals, such as the Rabies virus, which causes rabies in mammals, and numerous viruses that infect plants.

See also

References


External links

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Rhabdoviridae

  • DOI 10.5772 54598 image1

  • Fmicb-10-01490-g002

  • DOI 10 5772 54598 image2

  • Viruses-02-00995-g001

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Contributors: Prab R. Tumpati, MD