Propylphenidine

A dissociative anesthetic drug

Propylphenidine
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CAS Number	2201-35-6
PubChem	443495
DrugBank
ChemSpider	391667
KEGG

Propylphenidine is a chemical compound that belongs to the class of dissociative anesthetics. It is structurally related to diphenidine and is known for its NMDA receptor antagonistic properties. This compound has been studied for its potential effects on the central nervous system, particularly in relation to its dissociative and anesthetic properties.

Chemical Structure and Properties

Structure of Propylphenidine

Propylphenidine is chemically classified as an arylcyclohexylamine. Its IUPAC name is N-(1-phenylpropan-2-yl)aniline, and it has the molecular formula C₁₅H₁₇N. The compound consists of a phenyl ring attached to a propyl chain, which is further connected to an aniline group. This structure is similar to other dissociative anesthetics, which often feature an aryl group linked to an amine.

Pharmacology

Propylphenidine acts primarily as an NMDA receptor antagonist. The NMDA receptor is a subtype of glutamate receptor that plays a key role in synaptic plasticity and memory function. By inhibiting these receptors, propylphenidine can induce a state of dissociation, characterized by a sense of detachment from the environment and self. This mechanism is similar to that of other dissociative drugs such as ketamine and phencyclidine (PCP).

Effects

The effects of propylphenidine are primarily dissociative and anesthetic. Users may experience altered perceptions of reality, changes in sensory perception, and a sense of detachment from the body. These effects are dose-dependent and can vary significantly between individuals. At higher doses, propylphenidine can produce profound alterations in consciousness and perception, similar to other dissociative anesthetics.

Legal Status

The legal status of propylphenidine varies by country. In some jurisdictions, it may be classified as a controlled substance due to its potential for abuse and psychoactive effects. It is important for researchers and users to be aware of the legal implications of possessing or using this compound in their respective regions.

Safety and Toxicity

As with many dissociative anesthetics, the safety profile of propylphenidine is not well-established. Potential risks include neurotoxicity, psychological dependence, and adverse effects on mental health. Users should exercise caution and be aware of the potential for harmful interactions with other substances.

Related Compounds

Propylphenidine is related to several other compounds in the arylcyclohexylamine class, including:

• Diphenidine
• Methoxphenidine
• Ephenidine

These compounds share similar mechanisms of action and effects, although their potency and duration of action may differ.

Related Pages

• Dissociative drug
• NMDA receptor antagonist
• Arylcyclohexylamine