Prolymphocyte
Prolymphocyte is a type of cell that is found in the blood and bone marrow. It is larger than a lymphocyte and smaller than a blast cell. Prolymphocytes have a large nucleus (center part) and a small amount of cytoplasm (the material in a cell outside the nucleus). They are found in increased numbers in some types of leukemia and lymphoma.
Characteristics
Prolymphocytes are characterized by their large nucleus and small amount of cytoplasm. The nucleus of a prolymphocyte is round or oval and contains a prominent nucleolus. The cytoplasm is basophilic and contains few granules.
Role in Disease
Prolymphocytes are found in increased numbers in certain types of leukemia and lymphoma, specifically Prolymphocytic leukemia and Prolymphocytic lymphoma. These diseases are characterized by the overproduction of prolymphocytes, which can crowd out other types of cells in the blood and bone marrow.
Diagnosis and Treatment
The presence of prolymphocytes can be detected through a blood test or bone marrow biopsy. Treatment for diseases involving prolymphocytes typically involves chemotherapy, radiation therapy, or stem cell transplant.
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Contributors: Prab R. Tumpati, MD
