Persistent fetal vasculature
Persistent Fetal Vasculature (PFV)
Persistent Fetal Vasculature (PFV), also known as Persistent Hyperplastic Primary Vitreous (PHPV), is a rare congenital anomaly of the eye. Pronounced as /pərˈsɪstənt ˈfiːtəl ˌvæskjʊˈleɪʃər/, the term originates from the Latin words 'persistens' meaning 'continuing', 'fetus' meaning 'offspring', and 'vasculature' referring to the arrangement of blood vessels.
Description
PFV is characterized by a failure of the hyaloid artery system to regress normally during prenatal development. This results in a spectrum of structural abnormalities affecting the lens, vitreous humor, retina, and optic nerve. The condition can lead to vision loss or blindness if not treated promptly.
Symptoms
Symptoms of PFV may include microphthalmia (small eye), leukocoria (white pupil), elongated ciliary processes, and retrolental mass. Other signs may include cataract, glaucoma, and strabismus.
Causes
The exact cause of PFV is unknown. However, it is believed to be due to a disruption in the normal regression of the fetal vasculature during development. Some studies suggest a genetic component, but more research is needed to confirm this.
Treatment
Treatment for PFV is primarily surgical and aims to remove the abnormal tissue and correct any associated structural abnormalities. The specific surgical approach depends on the severity and location of the abnormalities.
Prognosis
The prognosis for PFV varies widely and depends on the severity of the condition and the success of treatment. Some individuals with PFV may have near-normal vision, while others may have severe vision loss or blindness.
See Also
References
External links
- Medical encyclopedia article on Persistent fetal vasculature
- Wikipedia's article - Persistent fetal vasculature
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