Pelareorep
Pelareorep
Pelareorep (pronunciation: puh-lair-ee-oh-rep) is a non-pathogenic, proprietary isolate of the unmodified reovirus used in the treatment of various types of cancer.
Etymology
The term "Pelareorep" is derived from the words "PEL" (from pelagic, meaning oceanic), "REO" (from reovirus), and "REP" (from replication). The name signifies the virus's ability to replicate in cancer cells.
Usage
Pelareorep is used in oncolytic virotherapy, a form of cancer treatment that uses viruses to destroy cancer cells. It is currently in the clinical trial phase for several types of cancer, including breast cancer, pancreatic cancer, and ovarian cancer.
Mechanism of Action
Pelareorep selectively replicates in and kills cancer cells, leaving normal cells unharmed. It does this by exploiting an inherent characteristic of cancer cells: their defective interferon response pathway. This allows the virus to replicate in these cells, leading to their destruction.
Related Terms
- Oncolytic virus: A virus that preferentially infects and kills cancer cells.
- Reovirus: A family of viruses that Pelareorep belongs to.
- Interferon: A group of signaling proteins made and released by host cells in response to the presence of several viruses.
External links
- Medical encyclopedia article on Pelareorep
- Wikipedia's article - Pelareorep
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