PFA-100
PFA-100
The PFA-100 (Platelet Function Assay-100) is a system used to measure platelet function. The PFA-100 is primarily used to diagnose platelet disorders and von Willebrand disease, and to monitor the effectiveness of antiplatelet therapy.
Pronunciation
PFA-100 is pronounced as "P-F-A-One-Hundred".
Etymology
The term PFA-100 is an acronym derived from Platelet Function Assay-100, indicating its use in assessing the function of platelets, which are crucial components in the blood clotting process.
Function
The PFA-100 system works by simulating the process of platelet adhesion and platelet aggregation, which are key steps in the formation of a blood clot. It does this by drawing blood through a small aperture under high shear conditions, mimicking the conditions that would occur in a damaged blood vessel.
Related Terms
- Platelet: A type of blood cell that helps prevent bleeding by forming clots.
- Platelet adhesion: The process by which platelets stick to the walls of damaged blood vessels.
- Platelet aggregation: The process by which platelets clump together to form a clot.
- Blood clot: A mass of platelets and other blood components that form to stop bleeding.
- Von Willebrand disease: A genetic disorder that results in excessive bleeding due to defective blood clotting.
- Antiplatelet therapy: Treatment with drugs that prevent platelets from clumping together to form clots.
External links
- Medical encyclopedia article on PFA-100
- Wikipedia's article - PFA-100
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