Malassezia globosa

Species of fungus

Malassezia globosa is a species of fungus in the genus Malassezia. It is a lipophilic yeast that is part of the normal microbiota of the skin in humans and other animals. M. globosa is known for its role in various skin conditions, including dandruff and seborrhoeic dermatitis.

Morphology and Physiology

Malassezia globosa is a small, spherical yeast that typically measures 2 to 4 micrometers in diameter. It is characterized by its ability to metabolize lipids, which is essential for its survival on the skin surface. Unlike many other fungi, M. globosa lacks the ability to synthesize certain fatty acids, relying instead on external sources of lipids.

Ecology

Malassezia globosa is found on the skin of humans and other warm-blooded animals. It thrives in areas rich in sebaceous glands, such as the scalp, face, and upper trunk. The yeast is part of the normal skin flora, but under certain conditions, it can proliferate excessively, leading to skin disorders.

Pathogenicity

While M. globosa is generally harmless, it can become pathogenic under certain conditions. It is implicated in the development of dandruff and seborrhoeic dermatitis, conditions characterized by flaking and itching of the skin. The yeast produces lipase enzymes that break down skin oils, releasing oleic acid, which can irritate the skin and lead to inflammation.

Genomics

The genome of Malassezia globosa has been sequenced, revealing insights into its metabolic capabilities and pathogenic potential. The genome is relatively small, reflecting its specialized lifestyle as a skin commensal. It contains genes for lipid metabolism, but lacks many of the genes found in other fungi for carbohydrate metabolism.

Treatment

Conditions associated with M. globosa overgrowth, such as dandruff and seborrhoeic dermatitis, are commonly treated with antifungal agents. Ketoconazole, selenium sulfide, and zinc pyrithione are effective in reducing the yeast population on the skin and alleviating symptoms.

Related pages

• Malassezia
• Dandruff
• Seborrhoeic dermatitis
• Fungi