Halofuginone

Halofuginone (pronunciation: /ˌhæloʊfjuːˈdʒiːnoʊn/) is a quinazolinone alkaloid that is derived from the plant species Dichroa febrifuga. It is a potent inhibitor of collagen type I and matrix metalloproteinase 2 (MMP-2) production, which are key factors in the process of fibrosis. Halofuginone has been studied for its potential therapeutic applications in treating fibrotic diseases and cancer.

Etymology

The term "halofuginone" is derived from the plant Dichroa febrifuga, also known as Chinese quinine or chang shan, from which the compound is extracted. The prefix "halo-" is derived from the Greek word "hals", meaning "salt", referring to the compound's halogenated structure.

Related Terms

Dichroa febrifuga: The plant species from which halofuginone is derived.
Quinazolinone: A class of organic compounds that halofuginone belongs to.
Collagen: A protein that halofuginone inhibits the production of.
Matrix metalloproteinase 2 (MMP-2): An enzyme that halofuginone inhibits the production of.
Fibrosis: A medical condition that halofuginone has potential therapeutic applications in treating.
Cancer: A group of diseases characterized by the uncontrolled growth and spread of abnormal cells, which halofuginone may have potential therapeutic applications in treating.