Orthopoxvirus inclusion bodies
Orthopoxvirus Inclusion Bodies
Orthopoxvirus inclusion bodies (pronunciation: or-tho-pox-vi-rus in-kloo-zhun bod-eez) are specific structures that are formed within the cells infected by the Orthopoxvirus family of viruses.
Etymology
The term "Orthopoxvirus" is derived from the Greek words "orthos" meaning "straight" and "pox" meaning "pustule". The term "inclusion bodies" refers to the structures that are included within the infected cells.
Definition
Orthopoxvirus inclusion bodies are intracytoplasmic or intranuclear structures that are formed in the cells infected by Orthopoxvirus. These structures are composed of viral proteins and genetic material, and they play a crucial role in the replication and assembly of new virus particles.
Types
There are two types of Orthopoxvirus inclusion bodies: Guarnieri bodies and A-type inclusion bodies.
- Guarnieri bodies are found in the cytoplasm of infected cells and are the sites of viral replication.
- A-type inclusion bodies are large, eosinophilic structures that contain mature virions. They are often associated with the Variola virus, the causative agent of smallpox.
Related Terms
- Orthopoxvirus: A genus of viruses in the family Poxviridae that includes Variola virus, Vaccinia virus, Cowpox virus, and Monkeypox virus.
- Guarnieri bodies: Cytoplasmic inclusions that are the sites of Orthopoxvirus replication.
- A-type inclusion bodies: Large, eosinophilic inclusions that contain mature Orthopoxvirus virions.
- Variola virus: The virus that causes smallpox.
- Smallpox: A highly contagious and deadly disease caused by the Variola virus.
External links
- Medical encyclopedia article on Orthopoxvirus inclusion bodies
- Wikipedia's article - Orthopoxvirus inclusion bodies
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