Globus pallidus internus
Globus Pallidus Internus
The Globus Pallidus Internus (pronunciation: gloh-buhs pal-i-duhs in-ter-nuhs) is a substructure of the basal ganglia, which is a group of nuclei in the brain associated with a variety of functions including control of voluntary motor movements, procedural learning, habit learning, eye movements, cognition, and emotion.
Etymology
The term "Globus Pallidus Internus" is derived from Latin, where "globus" means sphere, "pallidus" means pale, and "internus" refers to its position inside the Globus Pallidus.
Function
The Globus Pallidus Internus plays a crucial role in the regulation of voluntary movement. It receives signals from the striatum, another part of the basal ganglia, and sends inhibitory signals to the thalamus, which in turn sends signals to the motor cortex. This pathway is part of the indirect pathway of movement regulation.
Clinical Significance
In certain movement disorders such as Parkinson's disease and Dystonia, the Globus Pallidus Internus may be targeted for deep brain stimulation (DBS). DBS of the Globus Pallidus Internus has been shown to improve symptoms in these conditions.
Related Terms
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