GSK1016790A

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GSK1016790A is a potent and selective agonist of the TRPV4 ion channel. It is commonly used in scientific research to study the physiological and pathological roles of TRPV4 channels in various tissues.

Chemical Properties

GSK1016790A is a small molecule with a complex chemical structure. It is known for its high affinity and specificity towards the TRPV4 channel, making it a valuable tool in pharmacology and neuroscience research.

Mechanism of Action

GSK1016790A activates the TRPV4 channel, which is a member of the TRP family of ion channels. TRPV4 channels are permeable to calcium and other cations, and their activation leads to an influx of these ions into the cell. This can result in various cellular responses, including changes in cell volume, inflammation, and pain perception.

Applications in Research

GSK1016790A is widely used in research to investigate the role of TRPV4 channels in different physiological and pathological processes. Some of the key areas of research include:

• Pain: TRPV4 channels are involved in the sensation of pain, and GSK1016790A is used to study their role in nociception and hyperalgesia.
• Inflammation: Activation of TRPV4 channels can lead to inflammatory responses, and GSK1016790A is used to explore these mechanisms.
• Cardiovascular system: TRPV4 channels are expressed in the endothelium and smooth muscle cells of blood vessels, and GSK1016790A is used to study their role in vascular tone and blood pressure regulation.
• Respiratory system: TRPV4 channels are present in the lungs, and GSK1016790A is used to investigate their role in pulmonary function and respiratory diseases.

Safety and Handling

As with any research chemical, proper safety protocols should be followed when handling GSK1016790A. It should be used in a controlled laboratory environment, and appropriate personal protective equipment (PPE) should be worn.

See Also

• TRPV4
• Transient receptor potential channel
• Ion channel
• Pharmacology
• Neuroscience

References

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