Florbetapir
Florbetapir (pronounced: flor-bet-a-pir) is a radiopharmaceutical compound used in the imaging of beta-amyloid plaques in the brains of adults with cognitive impairment who are being evaluated for Alzheimer's Disease and other causes of cognitive decline.
Etymology
The name "Florbetapir" is derived from the compound's chemical structure, which includes fluorine (Flor-) and a beta-amyloid targeting ligand (-betapir).
Usage
Florbetapir is used in conjunction with Positron Emission Tomography (PET) imaging to estimate the density of beta-amyloid neuritic plaque in the brain. The presence of these plaques is a hallmark of Alzheimer's Disease and other forms of dementia.
Mechanism of Action
Florbetapir works by binding to beta-amyloid plaques in the brain, which can then be detected using PET imaging. The compound is injected into the bloodstream, where it crosses the Blood-Brain Barrier and binds to the plaques. The radioactive fluorine-18 isotope in the compound emits positrons that can be detected by the PET scanner, allowing for the visualization of the plaques.
Related Terms
See Also
External links
- Medical encyclopedia article on Florbetapir
- Wikipedia's article - Florbetapir
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