Flavan-4-ol

Flavan-4-ol is a type of flavonoid, a class of phytochemicals known for their diverse and potent biological activity. Flavan-4-ols are found in a variety of plants and are particularly abundant in certain types of tea, fruit, and cocoa.

Chemical Structure

Flavan-4-ols are characterized by a 15-carbon skeleton, which consists of two phenyl groups and a heterocyclic ring. This carbon structure can be abbreviated C6-C3-C6. The chemical structure of flavan-4-ols is similar to other flavonoids, but they are distinguished by the position of the B-ring and the oxidation state of the C-ring.

Biological Activity

Flavan-4-ols are known for their potent antioxidant activity. They can scavenge free radicals and chelate metal ions, which can reduce oxidative stress and potentially prevent oxidative damage to cells and tissues. Some studies have also suggested that flavan-4-ols may have anti-inflammatory, anti-cancer, and cardioprotective effects, although more research is needed to confirm these findings.

Dietary Sources

The primary dietary sources of flavan-4-ols are tea, fruit, and cocoa. Green tea and black tea are particularly rich sources of these compounds. In fruit, flavan-4-ols are found in high concentrations in berries, such as strawberries, blueberries, and blackberries. Cocoa and dark chocolate also contain significant amounts of flavan-4-ols.

Health Benefits

Due to their antioxidant, anti-inflammatory, and potential anti-cancer properties, flavan-4-ols have been associated with a variety of health benefits. These include protection against heart disease, improved vascular health, and reduced risk of certain types of cancer. However, while the potential health benefits of flavan-4-ols are promising, more research is needed to fully understand their effects in the human body.

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  Flavan-4-ol structure

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  Flavan-4-ol 3D ball-and-stick model