Fialuridine
Fialuridine
Fialuridine (pronounced as /fɪˈæl.jʊˌrɪˌdiːn/), also known as FIAU, is an antiviral drug that was initially developed for the treatment of hepatitis B. It is a nucleoside analogue, which means it mimics the structure of nucleosides, the building blocks of DNA and RNA.
Etymology
The term "Fialuridine" is derived from the chemical name 2'-fluoro-5-iodo-1-β-D-arabinofuranosyluracil. The abbreviation FIAU is an acronym of the chemical name.
Pharmacology
Fialuridine works by inhibiting the replication of the hepatitis B virus. It is incorporated into the viral DNA, causing premature termination of the DNA chain. This prevents the virus from multiplying and spreading.
History
Fialuridine was developed in the 1990s as a potential treatment for hepatitis B. However, clinical trials were halted when it was found to cause severe mitochondrial toxicity, leading to liver failure and death in some patients. As a result, Fialuridine is not currently used in clinical practice.
Related Terms
- Antiviral drug: A type of medication used to treat viral infections.
- Nucleoside analogue: A type of antiviral drug that mimics the structure of nucleosides.
- Hepatitis B: A viral infection that attacks the liver and can cause both acute and chronic disease.
- Mitochondrial toxicity: A harmful effect on the mitochondria, the energy-producing structures within cells.
External links
- Medical encyclopedia article on Fialuridine
- Wikipedia's article - Fialuridine
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