Fenofibrate/simvastatin
Fenofibrate/Simvastatin is a combination medication used in the treatment of high cholesterol and triglyceride levels. It contains two active ingredients: Fenofibrate and Simvastatin.
Etymology
The term "Fenofibrate" is derived from the chemical name "fenofibric acid", while "Simvastatin" is derived from the chemical name "simvastatin acid". Both names are derived from their respective chemical structures.
Pharmacology
Fenofibrate is a type of drug known as a fibrate, which works by reducing the levels of triglycerides and low-density lipoprotein (LDL) cholesterol in the blood, while increasing levels of high-density lipoprotein (HDL) cholesterol. Simvastatin is a statin, which works by inhibiting the enzyme HMG-CoA reductase, thereby reducing the production of cholesterol in the liver.
Indications
Fenofibrate/Simvastatin is indicated for the treatment of high cholesterol and triglyceride levels. It is used in conjunction with a low-fat diet and exercise to reduce the risk of heart disease and stroke.
Side Effects
Common side effects of Fenofibrate/Simvastatin include headache, stomach pain, and muscle pain. Serious side effects may include liver damage, kidney damage, and a rare but serious muscle condition known as rhabdomyolysis.
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Contributors: Prab R. Tumpati, MD