FOXQ1

FOXQ1

Symbol	FOXQ1
HGNC ID	3803
Alternative symbols	–
Entrez Gene	94234
OMIM	603252
RefSeq	NM_033260
UniProt	Q9C009
Chromosome	6p25.3
Locus supplementary data	–

FOXQ1 is a member of the forkhead box (FOX) family of transcription factors. These proteins are characterized by a distinct forkhead domain, which is a type of DNA-binding domain. The FOXQ1 gene is located on chromosome 6 at the p25.3 band.

Function

FOXQ1 plays a crucial role in the regulation of gene expression during development and cell differentiation. It is involved in various biological processes, including epithelial-mesenchymal transition (EMT), which is important for embryogenesis, tissue repair, and cancer metastasis.

Clinical Significance

Alterations in FOXQ1 expression have been associated with several types of cancer, including colorectal cancer, breast cancer, and gastric cancer. Overexpression of FOXQ1 can lead to increased tumorigenicity and metastatic potential of cancer cells.

Research

Studies have shown that FOXQ1 can interact with other signaling pathways, such as the Wnt signaling pathway, to promote cancer progression. It is also a potential target for therapeutic intervention in cancer treatment.

See Also

• Forkhead box protein
• Transcription factor
• Gene expression
• Cancer biology

External Links

• FOXQ1 Gene - NCBI
• FOXQ1 Protein - UniProt