ETS1

ETS1

Symbol	ETS1
HGNC ID	3487
Alternative symbols	–
Entrez Gene	2113
OMIM	164720
RefSeq	NM_005238
UniProt	P14921
Chromosome	–
Locus supplementary data	–

ETS1 is a gene that encodes a member of the ETS family of transcription factors. This family of transcription factors is characterized by the presence of a conserved ETS domain, which is responsible for binding to specific DNA sequences.

Function

The ETS1 protein plays a crucial role in the regulation of gene expression during various biological processes, including cell proliferation, differentiation, apoptosis, and angiogenesis. It is involved in the development of lymphoid and vascular systems and is essential for embryonic development.

Clinical Significance

Mutations or dysregulation of the ETS1 gene have been associated with various cancers, including leukemia, lymphoma, and breast cancer. Overexpression of ETS1 has been observed in tumor cells, where it may contribute to tumor progression and metastasis.

Interactions

ETS1 interacts with several other proteins and transcription factors to modulate gene expression. It can form complexes with cofactors such as CBP/p300 and AP-1, enhancing its transcriptional activity. These interactions are crucial for its role in cell signaling pathways.

Research

Ongoing research is focused on understanding the precise mechanisms by which ETS1 regulates gene expression and contributes to disease. Targeting ETS1 and its pathways is being explored as a potential therapeutic strategy in cancer treatment.

See Also

• Transcription factor
• Gene expression
• Cancer biology

External Links

• ETS1 Gene - NCBI
• ETS1 Protein - UniProt