Dehydrogenase

Dehydrogenase is a type of enzyme that catalyzes the removal of hydrogen atoms from a particular molecule, particularly in the context of a biochemical reaction. This process is known as oxidation.

Function

Dehydrogenases play a crucial role in the metabolism of carbohydrates, lipids, and proteins. They are involved in various metabolic pathways, including glycolysis, the citric acid cycle, and electron transport chain.

Types of Dehydrogenases

There are several types of dehydrogenases, each with a specific function. Some of the most common types include:

• Alcohol dehydrogenase - This enzyme is responsible for the breakdown of alcohols, including ethanol found in alcoholic beverages.
• Lactate dehydrogenase - This enzyme is involved in the conversion of lactate to pyruvate, an important step in the metabolic pathway.
• Glucose-6-phosphate dehydrogenase - This enzyme plays a key role in the pentose phosphate pathway, a process that generates NADPH and pentoses.
• Pyruvate dehydrogenase - This enzyme is crucial in the metabolic pathway, converting pyruvate into acetyl-CoA, which is then used in the citric acid cycle.

Clinical Significance

Dehydrogenase enzymes are often used as biomarkers in the diagnosis and monitoring of various diseases. For instance, elevated levels of lactate dehydrogenase can indicate tissue damage or disease. Similarly, deficiencies in glucose-6-phosphate dehydrogenase can lead to hemolytic anemia.

See Also

• Enzyme
• Metabolism
• Oxidation
• Biochemical reaction

References

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• Dehydrogenase
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  Sulcatone reductase reaction

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  Alcohol dehydrogenase

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  Krebs cycle: succinate to fumarate

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  Vanillyl-alcohol oxidase reaction

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  NAD+

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  NADP+

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  FAD

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  Aldehyde dehydrogenase mechanism