Clefamide

Clefamide

Chemical structure of Clefamide

Clefamide is a synthetic antibiotic belonging to the class of beta-lactam antibiotics. It is primarily used in the treatment of bacterial infections caused by susceptible strains of bacteria. Clefamide is known for its broad-spectrum activity and is often prescribed for infections of the respiratory tract, urinary tract, and skin.

Mechanism of Action

Clefamide works by inhibiting the synthesis of the bacterial cell wall. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which leads to the interruption of cell wall synthesis. This action ultimately results in the lysis and death of the bacterial cell. The effectiveness of Clefamide is due to its ability to resist degradation by certain bacterial beta-lactamase enzymes.

Pharmacokinetics

Clefamide is administered orally and is well absorbed from the gastrointestinal tract. It reaches peak plasma concentrations within 1 to 2 hours after administration. The drug is widely distributed throughout the body, including the lungs, liver, and kidneys. Clefamide is primarily excreted unchanged in the urine, making it effective for treating urinary tract infections.

Clinical Uses

Clefamide is indicated for the treatment of various infections, including:

• Pneumonia
• Bronchitis
• Cystitis
• Pyelonephritis
• Cellulitis

It is important to perform culture and sensitivity tests to ensure the causative organism is susceptible to Clefamide before initiating treatment.

Side Effects

Common side effects of Clefamide include:

• Nausea
• Diarrhea
• Rash
• Headache

Serious side effects, although rare, may include anaphylaxis and Clostridium difficile infection. Patients with a history of penicillin allergy should use Clefamide with caution.

Contraindications

Clefamide is contraindicated in patients with known hypersensitivity to beta-lactam antibiotics. It should be used with caution in patients with renal impairment and hepatic impairment.

Related Pages

• Antibiotic
• Beta-lactam antibiotic
• Bacterial infection
• Penicillin