Chlordimeform

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Chlordimeform

Structural formula of Chlordimeform

Chlordimeform is an insecticide and acaricide that was widely used in the past for controlling pests on various crops. It belongs to the class of formamidine compounds and was primarily used to manage mites and aphids on cotton, fruit, and vegetable crops.

Chemical Properties

Chlordimeform is a chemical compound with the molecular formula C10H13ClN2. It is characterized by its ability to interfere with the nervous system of insects, leading to their death. The compound is a white to light brown crystalline solid with a melting point of approximately 32°C.

Mode of Action

Chlordimeform acts as a neurotoxin by inhibiting the octopamine receptor in insects. Octopamine is a neurotransmitter that is analogous to norepinephrine in mammals. By disrupting the normal function of octopamine, chlordimeform causes paralysis and eventual death in target pests.

Usage

Chlordimeform was used extensively in agriculture due to its effectiveness against a wide range of pests. It was applied as a foliar spray on crops such as cotton, where it helped control bollworms and spider mites.

Environmental and Health Concerns

Despite its effectiveness, chlordimeform was found to have significant toxicological effects on humans and the environment. It is classified as a carcinogen and has been associated with adverse health effects such as skin irritation, respiratory issues, and potential neurotoxicity. Due to these concerns, its use has been banned or restricted in many countries.

Regulatory Status

Chlordimeform is no longer registered for use in many parts of the world, including the United States and the European Union. The Environmental Protection Agency (EPA) and other regulatory bodies have determined that the risks associated with its use outweigh the benefits.

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Contributors: Prab R. Tumpati, MD