Caspase 3

Caspase 3 is a member of the caspase family, a group of enzymes that play essential roles in apoptosis, necrosis, and inflammation. Caspase 3 is a crucial mediator of apoptosis, or programmed cell death, and is therefore a key factor in the maintenance of cellular homeostasis and the prevention of disease.

Structure

Caspase 3 is synthesized as an inactive enzyme precursor, or zymogen, that is activated through a process of proteolytic cleavage. The active enzyme is a heterotetramer, composed of two large and two small subunits. The active sites of caspase 3 are located within the large subunits.

Function

Caspase 3 is activated during the early stages of apoptosis and is responsible for the cleavage of several key proteins, leading to the morphological and biochemical changes associated with cell death. These include the cleavage of poly (ADP-ribose) polymerase (PARP), a DNA repair enzyme, and the inactivation of DNA fragmentation factor (DFF), leading to DNA fragmentation.

Role in Disease

Given its central role in apoptosis, dysregulation of caspase 3 activity has been implicated in a number of diseases. Overactivation of caspase 3 can lead to excessive cell death, contributing to conditions such as neurodegenerative diseases and ischemic injury. Conversely, reduced caspase 3 activity can result in insufficient cell death, contributing to the development of cancer.

Therapeutic Potential

Due to its role in disease, caspase 3 is a potential target for therapeutic intervention. Inhibitors of caspase 3 may be beneficial in conditions characterized by excessive cell death, while activators of caspase 3 may be useful in conditions characterized by insufficient cell death, such as cancer.

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  TNF signaling pathway

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  Extrinsic and intrinsic pathways to caspase-3 activation

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  Caspase 3 subunits

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  Caspase 3 active site