Programmed cell death

Programmed cell death (PCD) is a biological process that results in the death of cells in a controlled manner. This process is essential for the development and maintenance of multicellular organisms. PCD is categorized into several types, including apoptosis, autophagy, and necroptosis, each with distinct characteristics and molecular mechanisms.

Types of Programmed Cell Death

Apoptosis

Apoptosis is the most well-known type of PCD. It is characterized by cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation. Apoptosis can be triggered by various stimuli, including DNA damage, oxidative stress, and activation of death receptors on the cell surface.

Autophagy

Autophagy is a process that degrades and recycles cellular components. It is often activated in response to nutrient deprivation or other types of cellular stress. Autophagy can lead to cell death when it is excessively or inappropriately activated.

Necroptosis

Necroptosis is a form of PCD that is morphologically similar to necrosis, but is regulated by specific molecular mechanisms. It is typically triggered by signals such as TNFα, FasL, and TRAIL.

Regulation of Programmed Cell Death

The regulation of PCD involves a complex network of signaling pathways and proteins. Key regulators include the Bcl-2 family of proteins, caspases, and death receptors. Dysregulation of PCD can lead to various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Clinical Significance

Understanding the mechanisms of PCD has important implications for the treatment of various diseases. For example, drugs that can modulate apoptosis may be useful for treating cancer, while strategies to enhance autophagy may be beneficial for neurodegenerative diseases.

See Also

• Cell death
• Apoptosis
• Autophagy
• Necroptosis
• Bcl-2
• Caspases

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  Signal transduction pathways

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  Dying cells in the proliferative zone

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  Programmed cell death in the peripheral and central nervous system

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  A conserved apoptotic pathway in nematodes, mammals and fruitflies

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  DNA damage can lead to apoptosis or cancer